CAJ | 학술논문

血管内皮牛长因子是一种生长因子,在正常肺组织和多种肺部疾病中均有表达.通过血管内皮牛长因子受体发挥生理作用,具有促进内皮细胞分裂增殖、促血管生成、增加血管通透性及抗凋亡等作用.内皮抑素是一种内源性血管生成抑制剂,可以抑制血管内皮细胞增殖、迁移并诱导其调亡,从而达到抑制血管生成作用.在肺纤维化中二者均有异常表达,但具体作用机制尚未清楚.现就血管内皮生长因子、内皮抑素在肺纤维化病程中的作用作一综述,为肺纤维化的诊断和治疗提供新思路.
혈관내피우장인자시일충생장인자,재정상폐조직화다충폐부질병중균유표체.통과혈관내피우장인자수체발휘생리작용,구유촉진내피세포분렬증식、촉혈관생성、증가혈관통투성급항조망등작용.내피억소시일충내원성혈관생성억제제,가이억제혈관내피세포증식、천이병유도기조망,종이체도억제혈관생성작용.재폐섬유화중이자균유이상표체,단구체작용궤제상미청초.현취혈관내피생장인자、내피억소재폐섬유화병정중적작용작일종술,위폐섬유화적진단화치료제공신사로.
Vascular endothelial growth factor (VEGF) is an angiogenic factor, abundantly expressed in normal lung tissue and several respiratoy disorders. The biological activity of VEGF depends on its reaction with specific receptors. It can induce mitochysis, promot endothelial cell survival, increase angiogenesis, enhance vascular permeability and antiapoptotic effect. Endostatin (ES) is an endogenous angiogenic inhibitor. It inhibits endothelial cell migration and proliferation, induces apotosis in order to antiangiogenesis. They both expresses abnormally in pulmonary fibrosis, but the exact effects of them are not clear. This article summarizes the role of VEGF and ES in pulmonary fibrosis, in order to provide a new idea of diagnosis and therapeutic implications in pulmonary fibrosis.