CAJ | 학술논문

东方田鼠是我国非常有价值的野生动物资源之一.东方田鼠实验动物模型的建立已被列为国家的有关研究项目并得到了广泛全面的研究.日本血吸虫病是重要的人兽共患寄生虫病,仍是我国一个重要的公共卫生问题.而东方田鼠是迄今为止唯一发现具有天然抗血吸虫病的哺乳动物.目前,在东方田鼠牛物学特性、实验动物化研究、分子遗传学研究方面均有一定的进展,以期为东方田鼠的抗日本血吸虫特性研究提供理想的动物模型.该文就东方田鼠实验动物模型的建立及其在血吸虫病研究中的进展作一综述.
동방전서시아국비상유개치적야생동물자원지일.동방전서실험동물모형적건립이피렬위국가적유관연구항목병득도료엄범전면적연구.일본혈흡충병시중요적인수공환기생충병,잉시아국일개중요적공공위생문제.이동방전서시흘금위지유일발현구유천연항혈흡충병적포유동물.목전,재동방전서우물학특성、실험동물화연구、분자유전학연구방면균유일정적진전,이기위동방전서적항일본혈흡충특성연구제공이상적동물모형.해문취동방전서실험동물모형적건립급기재혈흡충병연구중적진전작일종술.
Microtus fortis is a valuable resource of wild animals in China.To develop an experimental model of Microtus fortis has been listed as a research project in national program and under extensive study.Up to date,schistosomiasis japonicum is an important zoonosis,which remain8 an important public health issue in China.Microtus fortis is a unique wild mammalian resistant to schistosomiasis 80 far.At present,more intensive studies are needed in its taxonomy,anatomy,purification,embryo cryopreservation and transplantation,especiany in molecular genetics to develop a useful experimental model for researches on the resistant mechanism to S.japonicum infection and transgenic breeding of schistosomiasis-resistant animal in laboratory.In this paper.the progress in establishment of Microtus fortis experimental model and its application in the research of schistosomiasis japonica were reviewed.