中华临床营养杂志
中華臨床營養雜誌
중화림상영양잡지
CHINESE JOURNAL OF CLINICAL NUTRITION
2011年
3期
162-166
,共5页
王云玲%曹景玉%吴力群%刘加秀
王雲玲%曹景玉%吳力群%劉加秀
왕운령%조경옥%오력군%류가수
ω-3脂肪酸%肝切除术%炎症反应%免疫功能
ω-3脂肪痠%肝切除術%炎癥反應%免疫功能
ω-3지방산%간절제술%염증반응%면역공능
ω-3 fatty acids%Hepatectomy%Inflammatory reaction%Immunologic function
目的 探讨ω-3脂肪酸对肝部分切除术后患者炎症反应和免疫功能的影响.方法 肝部分切除患者82例参加本研究,所有患者按随机数表法随机分为两组,术后给予等热量、等氮肠外营养治疗.对照组单纯使用中长链脂肪乳,研究组使用中长链脂肪乳联合ω-3脂肪酸.分别于术前、术后第1、3、7天抽取空腹静脉血,检测肝功能(总蛋白、白蛋白、前白蛋白、谷丙转氨酶、谷草转氨酶)、凝血功能(国际标准化比值)、免疫球蛋白(IgA、IgG、IgM)、CD3、CD4/CD8及外周血白细胞计数等.结果 术后第7天研究组患者血清总蛋白(61.40±5.12)g/L显著高于对照组(58.54±5.53)g/L(P=0.018),研究组谷草转氨酶(32.37±11.92)U/L显著低于对照组(42.50±29.97)U/L(JP=0.048),研究组IgA(2.67±1.01)g/L显著高于对照组(2.15±0.77)g/L(P=0.027),研究组IL-1β(7.88±6.45)pg/ml显著低于对照组(12.98±11.07)pg/ml(P=0.034),研究组IL-2(24.98±20.38)pg/ml显著低于对照组(43.09±20.74)pg/ml(P:0.002).两组患者术后第7天外周血白细胞及凝血功能指标差异无统计学意义.结论 ω-3脂肪酸有助于改善肝部分切除术后患者免疫功能及肝功能,降低炎症反应.
目的 探討ω-3脂肪痠對肝部分切除術後患者炎癥反應和免疫功能的影響.方法 肝部分切除患者82例參加本研究,所有患者按隨機數錶法隨機分為兩組,術後給予等熱量、等氮腸外營養治療.對照組單純使用中長鏈脂肪乳,研究組使用中長鏈脂肪乳聯閤ω-3脂肪痠.分彆于術前、術後第1、3、7天抽取空腹靜脈血,檢測肝功能(總蛋白、白蛋白、前白蛋白、穀丙轉氨酶、穀草轉氨酶)、凝血功能(國際標準化比值)、免疫毬蛋白(IgA、IgG、IgM)、CD3、CD4/CD8及外週血白細胞計數等.結果 術後第7天研究組患者血清總蛋白(61.40±5.12)g/L顯著高于對照組(58.54±5.53)g/L(P=0.018),研究組穀草轉氨酶(32.37±11.92)U/L顯著低于對照組(42.50±29.97)U/L(JP=0.048),研究組IgA(2.67±1.01)g/L顯著高于對照組(2.15±0.77)g/L(P=0.027),研究組IL-1β(7.88±6.45)pg/ml顯著低于對照組(12.98±11.07)pg/ml(P=0.034),研究組IL-2(24.98±20.38)pg/ml顯著低于對照組(43.09±20.74)pg/ml(P:0.002).兩組患者術後第7天外週血白細胞及凝血功能指標差異無統計學意義.結論 ω-3脂肪痠有助于改善肝部分切除術後患者免疫功能及肝功能,降低炎癥反應.
목적 탐토ω-3지방산대간부분절제술후환자염증반응화면역공능적영향.방법 간부분절제환자82례삼가본연구,소유환자안수궤수표법수궤분위량조,술후급여등열량、등담장외영양치료.대조조단순사용중장련지방유,연구조사용중장련지방유연합ω-3지방산.분별우술전、술후제1、3、7천추취공복정맥혈,검측간공능(총단백、백단백、전백단백、곡병전안매、곡초전안매)、응혈공능(국제표준화비치)、면역구단백(IgA、IgG、IgM)、CD3、CD4/CD8급외주혈백세포계수등.결과 술후제7천연구조환자혈청총단백(61.40±5.12)g/L현저고우대조조(58.54±5.53)g/L(P=0.018),연구조곡초전안매(32.37±11.92)U/L현저저우대조조(42.50±29.97)U/L(JP=0.048),연구조IgA(2.67±1.01)g/L현저고우대조조(2.15±0.77)g/L(P=0.027),연구조IL-1β(7.88±6.45)pg/ml현저저우대조조(12.98±11.07)pg/ml(P=0.034),연구조IL-2(24.98±20.38)pg/ml현저저우대조조(43.09±20.74)pg/ml(P:0.002).량조환자술후제7천외주혈백세포급응혈공능지표차이무통계학의의.결론 ω-3지방산유조우개선간부분절제술후환자면역공능급간공능,강저염증반응.
Objective To investigate the effects of ω-3 fatty acids (FA) on inflammatory reaction and immunologic function of patients after hepatectomy. Methods Totally 82 patients were randomized into control group and ω-3 FA group. Both groups received parenteral nutrition (PN) with equal nitrogen and calories. Patients in the control group received medium and long-chain lipid emulsion, and those in the ω-3 FA group received ω-3 FA combined with medium and long-chain lipid emulsion. Liver function test (serum total protein, prealbumin, albumin ,aspartate aminotransferase, alanine aminotransferase) , blood coagulation function (international normalized ratio) , immune globubin (IgA, IgG, and IgM) , CD3 and CD4/CD8 were measured on the first, third, and seventh post-operative day. Results Serum total protein in the ω-3 FA group [(61. 40 ±5. 12) g/L] was significantly higher than in the control group [(58. 54 ± 5. 53 ) g/L] (P = 0. 018 ) . Aspartate aminotransferase in the ω-3 FA group [(32. 37 ± 11. 92) U/L] was significantly lower than in the control group [(42. 50 ± 29. 97) U/L] (P = 0. 048). IgA in the ω-3 FA group [(2. 67 ± 1. 01) g/L] was significantly higher than in the control group [(2. 15 ±0.77) g/L] (P=0.027). IL-1β in the ω-3 FA group [(7.88 ±6.45) pg/ml] was significantly lower than in the control group [(12. 98 ± 11. 07) pg/ml] (P = 0.034). IL-2 in the ω-3 FA group [(24.98±20.38) pg/ml] was significantly lower than the control group [(43. 09 ± 20. 74) pg/ml] (P = 0.002). The white blood cell counts and coagulation function were not significantly different between two groups. Conclusion Total PN containing ω-3 FA can effectively improve immunologic function and liver function of patients after hepatectomy.
