中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2008年
7期
625-628
,共4页
潘立峰%吴敏兰%赵志荣%单保恩%郑宝军%邵建富
潘立峰%吳敏蘭%趙誌榮%單保恩%鄭寶軍%邵建富
반립봉%오민란%조지영%단보은%정보군%소건부
胃肿瘤%埃兹蛋白%ICAM-1%免疫组化
胃腫瘤%埃玆蛋白%ICAM-1%免疫組化
위종류%애자단백%ICAM-1%면역조화
Stomach carcinoma%Ezrin%ICAM-1%Immunohistochemistry
目的 探讨Ezrin、ICAM-1在胃癌中的表达及其意义.方法 应用免疫组化S-P法检测Ezrin、ICAM-1在78例胃癌组织、30例胃良性病变组织、30例正常胃黏膜组织的表达,分析其与临床病理特征的关系及相关性.结果 ①胃癌组织中Ezrin、ICAM-1蛋白表达阳性率显著高于胃良性病变及正常胃黏膜组织(P<0.01),有淋巴结转移组明显高于无淋巴结转移组(P<0.05),13、T4组明显高于T1、T2组(P<0.05),Ⅲ、Ⅳ期组明显高于Ⅰ、Ⅱ期组(P<0.05).②胃癌组织中Ezrin蛋白表达水平与粘附分子ICAM-1蛋白表达水平之间呈正相关(r=0.46,P=0.00).③联合检测Ezrin、粘附分子ICAM-1在胃癌组织中的表达可明显提高检测胃癌转移的敏感性和特异性(P<0.05).结论 Ezrin、粘附分子ICAM-1的过度表达与胃癌的发生发展及侵袭转移有关,联合检测两种指标能明显提高检测胃癌转移的敏感性和特异性.
目的 探討Ezrin、ICAM-1在胃癌中的錶達及其意義.方法 應用免疫組化S-P法檢測Ezrin、ICAM-1在78例胃癌組織、30例胃良性病變組織、30例正常胃黏膜組織的錶達,分析其與臨床病理特徵的關繫及相關性.結果 ①胃癌組織中Ezrin、ICAM-1蛋白錶達暘性率顯著高于胃良性病變及正常胃黏膜組織(P<0.01),有淋巴結轉移組明顯高于無淋巴結轉移組(P<0.05),13、T4組明顯高于T1、T2組(P<0.05),Ⅲ、Ⅳ期組明顯高于Ⅰ、Ⅱ期組(P<0.05).②胃癌組織中Ezrin蛋白錶達水平與粘附分子ICAM-1蛋白錶達水平之間呈正相關(r=0.46,P=0.00).③聯閤檢測Ezrin、粘附分子ICAM-1在胃癌組織中的錶達可明顯提高檢測胃癌轉移的敏感性和特異性(P<0.05).結論 Ezrin、粘附分子ICAM-1的過度錶達與胃癌的髮生髮展及侵襲轉移有關,聯閤檢測兩種指標能明顯提高檢測胃癌轉移的敏感性和特異性.
목적 탐토Ezrin、ICAM-1재위암중적표체급기의의.방법 응용면역조화S-P법검측Ezrin、ICAM-1재78례위암조직、30례위량성병변조직、30례정상위점막조직적표체,분석기여림상병리특정적관계급상관성.결과 ①위암조직중Ezrin、ICAM-1단백표체양성솔현저고우위량성병변급정상위점막조직(P<0.01),유림파결전이조명현고우무림파결전이조(P<0.05),13、T4조명현고우T1、T2조(P<0.05),Ⅲ、Ⅳ기조명현고우Ⅰ、Ⅱ기조(P<0.05).②위암조직중Ezrin단백표체수평여점부분자ICAM-1단백표체수평지간정정상관(r=0.46,P=0.00).③연합검측Ezrin、점부분자ICAM-1재위암조직중적표체가명현제고검측위암전이적민감성화특이성(P<0.05).결론 Ezrin、점부분자ICAM-1적과도표체여위암적발생발전급침습전이유관,연합검측량충지표능명현제고검측위암전이적민감성화특이성.
Objective To investigate the expression and significance of Ezrin and ICAM-1 in gastric carci- noma.Methods The expression of Ezrin and ICAM-1 were examined by S-P immunohistochemistry assays in 78 ca- ses of gastric carcinoma.30 cases of nonmalignant tissue and 30 cases of normal stomach.The relationship between them and their pathological characteristics were analyzed.Results ①The expression rates of Ezrin and ICAM-1 were obviously higher in carcinoma group than that of nonmalignant group and normal group(P<0.01),in the lym- phatic metastasis group than that in non lymphatic metastasis group(P<0.05),and in T3.T4 group and than that in T1,T2 group(P<0.05).②The expression level of ICAM-1 was positively related with that of Ezrin(r=0.46. P=0.00).③The test of the expression of Ezrin and ICAM-1 simutaniously could obviously increase the sensitivity and specificy for detecting the metastasis of stomach malignant tumor(P<0.05).Condusion The over expression of Ezrin and ICAM-1 is related to the pathogenesis and invasion as well as metastasis of stomach carcinoma.The combined detection of two markers can obviously increase the sensitivity and specificy for predicting metastasis of stomach carcinoma.
