CAJ | 학술논문

目的探讨突发性耳聋患者血清内脂素( visfatin)和视黄醇结合蛋白4(RBP4)的含量变化,及其在突发性耳聋发生过程中的作用和意义.方法采用酶联免疫(ELISA)法检测血清内脂素和RBP4含量；检测102例突发性耳聋患者、35例其他疾病对照组和30例正常健康对照组的血清内脂素和RBP4含量,并比较治疗前后血清内脂素和RBP4的测定结果.结果突发性耳聋患者治疗后血清内脂素[(24.26±2.17) μg/L]和RBP4含量[(46.65 ±5.26) mg/L]显著高于其它疾病对照组[内脂素:(20.67±2.14) μg/L; RBP4:(34.37±5.73) mg/L]和健康对照组[内脂素:(17.61±2.45)μg/L; RBP4:(24.82±5.24)mg/L](t=10.38,10.41,12.16,15.06,P＜0.01),较治疗前明显降低[内脂素:(32.24±2.37) μg/L;RBP4:(57.43±6.19) mg/L](t=17.25,15.12,P＜0.01).同时重度组突发性耳聋患者血清内脂素[(36.52±2.46)μg/L]和RBP4[(67.17±5.92)mg/L]浓度明显高于中度组[内脂素:(28.92±2.26) μg/L; RBP4:( 55.34±5.95)mg/L](t=11.21,11.17,P＜0.01),中度组患者明显高于轻度组[内脂素:(25.31±2.32) μg/L; RBP4:(47.48±5.82) mg/L],且差异有统计学意义(t=10.43,10.49,P＜0.01).突发性耳聋患者血清内脂素和RBP4含量之间呈正相关(r =0.68,P＜0.01).结论血清内脂素和RBP4水平的变化与突发性耳聋病情严重程度密切相关.
목적 탐토돌발성이롱환자혈청내지소( visfatin)화시황순결합단백4(RBP4)적함량변화,급기재돌발성이롱발생과정중적작용화의의.방법 채용매련면역(ELISA)법검측혈청내지소화RBP4함량；검측102례돌발성이롱환자、35례기타질병대조조화30례정상건강대조조적혈청내지소화RBP4함량,병비교치료전후혈청내지소화RBP4적측정결과.결과 돌발성이롱환자치료후혈청내지소[(24.26±2.17) μg/L]화RBP4함량[(46.65 ±5.26) mg/L]현저고우기타질병대조조[내지소:(20.67±2.14) μg/L; RBP4:(34.37±5.73) mg/L]화건강대조조[내지소:(17.61±2.45)μg/L; RBP4:(24.82±5.24)mg/L](t=10.38,10.41,12.16,15.06,P＜0.01),교치료전명현강저[내지소:(32.24±2.37) μg/L;RBP4:(57.43±6.19) mg/L](t=17.25,15.12,P＜0.01).동시중도조돌발성이롱환자혈청내지소[(36.52±2.46)μg/L]화RBP4[(67.17±5.92)mg/L]농도명현고우중도조[내지소:(28.92±2.26) μg/L; RBP4:( 55.34±5.95)mg/L](t=11.21,11.17,P＜0.01),중도조환자명현고우경도조[내지소:(25.31±2.32) μg/L; RBP4:(47.48±5.82) mg/L],차차이유통계학의의(t=10.43,10.49,P＜0.01).돌발성이롱환자혈청내지소화RBP4함량지간정정상관(r =0.68,P＜0.01).결론 혈청내지소화RBP4수평적변화여돌발성이롱병정엄중정도밀절상관.
Objective To study the role and clinical significance of serum visfatin and retinol binding protein 4 (RBP4) in idiopathic sudden sensorineural hearing loss by measuring the change of their levels in the patients with idiopathic sudden sensorineural hearing loss.Methods The levels of visfatin and RBP4 were determined by ELISA method in the 102 idiopathic sudden sensorineural hearing loss patients who were observed at two different time points ( before and after treatment),and thirty-five patients with other neurologic diseases (20 with sciatica,16 with trigeminal neuralgia) and thirty healthy people were used as control.Results The levels of visfatin and RBP4 in the serum of patients with idiopathic sudden sensorineural hearing loss after treatment [Visfatin (24.26 ± 2.17 ) μg/L; RBP4 (46.65 ± 5.26 ) mg/L]were markedly higher than the group with other neurologic diseases [Visfatin ( 20.67 ± 2.14 ) μ g/L; RBP4(34.37 ±5.73)mg/L] and the healthy control group[Visfatin(17.61 ±2.45) μg/L; RBP4 (24.82 ±5.24)mg/L] ( t =10.38,10.41,12.16,15.06,P ＜0.01),and it was significantly less than that before treatment [Visfatin(32.24 ± 2.37) μ /L; RBP4 ( 57.43 ± 6.19 ) mg/L] ( t =17.25,15.12,P ＜ 0.01 ).The levels visfatin and RBP4 in serum of severe group with idiopathic sudden sensorineural hearing loss [Visfatin ( 36.52 ± 2.46 ) μg/L; RBP4 (67.17 ± 5.92 ) mg/L] were markedly higher than those in the moderate group[Visfatin(28.92 ±2.26)μg/L; RBP4 (55.34±5.95)mg/L]( t =11.21,11.17,P ＜0.01).The levels visfatin and RBP4 in serum of moderate group were markedly higher than those in the mild group [Visfatin ( 25.31 ± 2.32 ) μg/L; RBP4 ( 47.48 ± 5.82 ) mg/L],all these differences were statistically significant( t =10.43,10.49,P ＜0.01 ).There was a positive correlation between visfatin and RBP4 in patients with idiopathic sudden sensorineural hearing loss ( r =0.68,P ＜ 0.01 ).Conclusions The levels of serum visfatin and RBP4 have instructive significance in idiopathic sudden sensorineural hearing loss treating and prognosis estimating