CAJ | 학술논문

目的探讨胆管癌组织中过氧化物酶体增长因子活化受体γ(PPARγ)和维甲酸类X受体(RXRα)蛋白的表达与胆管癌临床病理特征的关系及其对预后的影响.方法采用免疫组化法检测69例胆管癌以及12例非肿瘤胆管黏膜上皮组织中PPARγ与RXRα的表达情况,并分析其与临床病理参数及预后的关系.结果 69例胆管癌组织、12例非肿瘤胆管黏膜上皮组织中PPARγ表达阳性率分别为59.4%、0;69例胆管癌组织、12非肿瘤胆管黏膜上皮组织中RxRα表达阳性率分别为78.3%、20%,差异有统计学意义.PPARγ蛋白的阳性表达与胆管癌TNM分期、淋巴结转移密切相关,PPARγ蛋白阳性表达组胆管癌病人的预后差.PPARγ与RXRα存在明显的正相关关系.结论 PPARγ表达与胆管癌临床病理特征密切相关.PPARγ和RXRα两者可能参与了胆管上皮癌变过程.
목적 탐토담관암조직중과양화물매체증장인자활화수체γ(PPARγ)화유갑산류X수체(RXRα)단백적표체여담관암림상병리특정적관계급기대예후적영향.방법 채용면역조화법검측69례담관암이급12례비종류담관점막상피조직중PPARγ여RXRα적표체정황,병분석기여림상병리삼수급예후적관계.결과 69례담관암조직、12례비종류담관점막상피조직중PPARγ표체양성솔분별위59.4%、0;69례담관암조직、12비종류담관점막상피조직중RxRα표체양성솔분별위78.3%、20%,차이유통계학의의.PPARγ단백적양성표체여담관암TNM분기、림파결전이밀절상관,PPARγ단백양성표체조담관암병인적예후차.PPARγ여RXRα존재명현적정상관관계.결론 PPARγ표체여담관암림상병리특정밀절상관.PPARγ화RXRα량자가능삼여료담관상피암변과정.
Objective To evaluate the expression of peroxisome proliferator-activated receptor γ(PPARγ)and retinoid x receptorα(RXRα)in cholangiocarcinoma to explore its relation to clinicopathological factors and investigate its impact on prognosis.Methods Expression of PPARγ and RXRα was detected by immunohistochemistry in 69 cases of cholangiocarcinoma and 12 non-tumor cases.The relation of PPARγ and RXRα expression to clinicopathological parameters and prognosis was determined.Results The expression rates of PPARγ in 69 cases of cholangiocarcinoma and 12 non-tumor cases were 59.4% and 0, respectively(P＜0.05).The expression rates of RXRα in 69 cases of cholangiocarcinoma and 12 non-tumor cases were 78.3% and 20%, respectively.There were significant differences between the 2 groups in PPARγ and RXRα expression.PPARγ expression was associated with TNM clinical stages and lymph node metastasis.According to univariate survival analysis,PPARγ expression was correlated with poor prognosis(P＜0.05).There was positive correlation between PPARγ and RXRα.Conclusion The expression of PPARγis significantly correlated with the clinicopathological characteristics and biological behaviors of cholangiocarcinoma.PPARγ and RXRα expression may play an important role during tumorigenesis.