中华实验和临床病毒学杂志
中華實驗和臨床病毒學雜誌
중화실험화림상병독학잡지
CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL VIROLOGY
2011年
5期
338-341
,共4页
易为%李明慧%胡玉红%刘凤%张艳丽%刘雪净%郝红晓%宋淑静%刘颖%李杏红%孙继云%刘敏%成军%谢尧
易為%李明慧%鬍玉紅%劉鳳%張豔麗%劉雪淨%郝紅曉%宋淑靜%劉穎%李杏紅%孫繼雲%劉敏%成軍%謝堯
역위%리명혜%호옥홍%류봉%장염려%류설정%학홍효%송숙정%류영%리행홍%손계운%류민%성군%사요
肝炎表面抗原,乙型%疾病传播,垂直%肝炎病毒,乙型%肝炎疫苗,乙肝
肝炎錶麵抗原,乙型%疾病傳播,垂直%肝炎病毒,乙型%肝炎疫苗,乙肝
간염표면항원,을형%질병전파,수직%간염병독,을형%간염역묘,을간
Hepatitis B surface antigens%Disease transmission,vertical%Hepatitis B virus%Hepatitis B vaccines
目的 探讨HBV慢性感染孕妇新生儿出生后不同时期静脉血HBsAg含量变化对HBV母婴传播阻断失败的预测价值.方法 以HBsAg、HBeAg双阳性、血清HBV DNA含量≥l05拷贝/ml慢性HBV感染孕妇所娩新生儿150例为研究对象,出生后立即注射乙肝免疫球蛋白200 IU,并按0、1和6个月程序接种乙肝疫苗10～20 μg.分别于新生儿出生时、生后1个月、生后7个月采取静脉血检测HBV血清学指标,分析新生儿不同时期静脉血HBsAg含量对HBV母婴传播阻断失败的预测.结果 共有11例新生儿发生HBV母婴阻断失败.新生儿出生时、生后1个月、生后7个月HBsAg阳性率分别为41.26％、10.49％、7.69％,HBeAg阳性率分别为97.90％、65.73％、13.29％.以出生时HBsAg≥0.05和HBsAg≥1 IU/ml预测HBV母婴传播阻断失败,阳性预测价值分别为18.64％和70％;生后1个月HBsAg≥0.05和HBsAg≥1 IU/ml的阳性预测价值分别为73.33％和100％.结论 出生时静脉血HBsAg含量≥1 IU/ml时应高度怀疑HBV母婴传播的失败.生后1个月HBsAg≥1IU/ml对母要传播阻断失败有高度的预测价值,如何提高出生时和生后1个月静脉血HBsAg阳性新生儿的HBV感染阻断率是以后研究的重点.
目的 探討HBV慢性感染孕婦新生兒齣生後不同時期靜脈血HBsAg含量變化對HBV母嬰傳播阻斷失敗的預測價值.方法 以HBsAg、HBeAg雙暘性、血清HBV DNA含量≥l05拷貝/ml慢性HBV感染孕婦所娩新生兒150例為研究對象,齣生後立即註射乙肝免疫毬蛋白200 IU,併按0、1和6箇月程序接種乙肝疫苗10～20 μg.分彆于新生兒齣生時、生後1箇月、生後7箇月採取靜脈血檢測HBV血清學指標,分析新生兒不同時期靜脈血HBsAg含量對HBV母嬰傳播阻斷失敗的預測.結果 共有11例新生兒髮生HBV母嬰阻斷失敗.新生兒齣生時、生後1箇月、生後7箇月HBsAg暘性率分彆為41.26％、10.49％、7.69％,HBeAg暘性率分彆為97.90％、65.73％、13.29％.以齣生時HBsAg≥0.05和HBsAg≥1 IU/ml預測HBV母嬰傳播阻斷失敗,暘性預測價值分彆為18.64％和70％;生後1箇月HBsAg≥0.05和HBsAg≥1 IU/ml的暘性預測價值分彆為73.33％和100％.結論 齣生時靜脈血HBsAg含量≥1 IU/ml時應高度懷疑HBV母嬰傳播的失敗.生後1箇月HBsAg≥1IU/ml對母要傳播阻斷失敗有高度的預測價值,如何提高齣生時和生後1箇月靜脈血HBsAg暘性新生兒的HBV感染阻斷率是以後研究的重點.
목적 탐토HBV만성감염잉부신생인출생후불동시기정맥혈HBsAg함량변화대HBV모영전파조단실패적예측개치.방법 이HBsAg、HBeAg쌍양성、혈청HBV DNA함량≥l05고패/ml만성HBV감염잉부소면신생인150례위연구대상,출생후립즉주사을간면역구단백200 IU,병안0、1화6개월정서접충을간역묘10～20 μg.분별우신생인출생시、생후1개월、생후7개월채취정맥혈검측HBV혈청학지표,분석신생인불동시기정맥혈HBsAg함량대HBV모영전파조단실패적예측.결과 공유11례신생인발생HBV모영조단실패.신생인출생시、생후1개월、생후7개월HBsAg양성솔분별위41.26％、10.49％、7.69％,HBeAg양성솔분별위97.90％、65.73％、13.29％.이출생시HBsAg≥0.05화HBsAg≥1 IU/ml예측HBV모영전파조단실패,양성예측개치분별위18.64％화70％;생후1개월HBsAg≥0.05화HBsAg≥1 IU/ml적양성예측개치분별위73.33％화100％.결론 출생시정맥혈HBsAg함량≥1 IU/ml시응고도부의HBV모영전파적실패.생후1개월HBsAg≥1IU/ml대모요전파조단실패유고도적예측개치,여하제고출생시화생후1개월정맥혈HBsAg양성신생인적HBV감염조단솔시이후연구적중점.
Objective In this study,we discuss the predictive value of different content of HBsAg in different stages of neotal venous blood on failure of blocking mother to infant transmission of HBV.Methods 150 infants born of chronically HBV infected mothers who were positive of both HBsAg and HBeAg and who also had a HBV DNA virus load above 105 copies/ml were enrolled.These infants were given hepatitis B virus immune globin (HBIG) 200 IU immediately after birth and were given hepatitis B vaccine 10 or 20 μg at brith,1 month and 6 months after birth.HBV serological index of these infants were test at birth,1 month and 7 months after birth respectively.Different content of HBsAg in different stages of neonatal venus blood were analyzed to predict the failure of blocking mother to infant transmission of HBV.Results 11 infants failed in blocking of HBV mother to infant transmission.The positive rate of HBsAg at birth,1 month and 7 months after birth were 41.26％,10.49％ and 7.69％ respectively,and were 97.90％,65.73％ and 13.29％ of HBeAg.The positive predictive value of HBsAg≥0.05 and HBsAg≥ 1 IU/ml at birth were 18.64％ and 70％ respectively,and were 73.33％ and 100％ one month after birth.Conclusions Infants with HBsAg ≥ 1 IU/ml at birth should be suspicious of failure on blocking HBV mother-to-infant transmission and it should be more credible if the infant has HBsAg≥ 1 IU/ml one month after birth.How to improve the blocking rate of neonates who were positive of HBsAg at birth and one month after birth should be the focus of our future research.
