CAJ | 학술논문

目的探讨通过膀胱出口部分梗阻建立低顺应性膀胱模型的方法.方法将成年雄性新西兰兔20只随机分为2组:对照组10只于实验开始时行尿动力学检测;梗阻组10只应用膀胱颈部分结扎的方法,造成膀胱出口部分梗阻,分别于8、12、14周进行尿动力检查,观察膀胱顺应性和膀胱重量的变化.结果　膀胱重量:梗阻14周组(14.1±2.3)g显著高于对照组(2.7±0.5)g(P＜0.01);膀胱顺应性:梗阻14周膀胱顺应性(1.21±0.44)ml/cmH2O显著低于对照组(2.68±0.67)ml/cm H2O(P＜0.01).结论　结扎法致膀胱出口部分梗阻是建立低顺应性膀胱模型的可靠方法.
목적 탐토통과방광출구부분경조건립저순응성방광모형적방법.방법 장성년웅성신서란토20지수궤분위2조:대조조10지우실험개시시행뇨동역학검측;경조조10지응용방광경부분결찰적방법,조성방광출구부분경조,분별우8、12、14주진행뇨동력검사,관찰방광순응성화방광중량적변화.결과　방광중량:경조14주조(14.1±2.3)g현저고우대조조(2.7±0.5)g(P＜0.01);방광순응성:경조14주방광순응성(1.21±0.44)ml/cmH2O현저저우대조조(2.68±0.67)ml/cm H2O(P＜0.01).결론　결찰법치방광출구부분경조시건립저순응성방광모형적가고방법.
Objective To investigate the approaches of establishing the model of low compliance bladder by partial bladder outlet obstruction. Methods Twenty adult male New Zealand rabbits were randomly divided into 2 groups (n = 10 each group). In control group the rabbits were given urodynamic examination at the beginning. In obstruction group, the bladder neck of 10 adult male New Zealand rabbits was partially ligated. Eight, 12 and 14 weeks later, urodynamic examinations were carried out to observe the changes of bladder compliance. Results The bladder weight was increased significantly in obstruction group at 14th week ( 14. 1 ±2. 3) g as compared with that in control group (2. 7 ±0. 5) g,P ＜0. 01. The compliance in obstruction group at 14th week (1.21 ± 0. 44) ml/cm H2O was less than in control group (2. 68 ± 0. 67) ml/cm H2O,P ＜ 0. 01. Conclusion Bladder neck ligation-induced bladder partial outlet obstruction is a reliable method to build the model of low compliance bladder.