肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2012年
2期
98-101
,共4页
毕益明%付艳%陈秀芳%李新军%陈元
畢益明%付豔%陳秀芳%李新軍%陳元
필익명%부염%진수방%리신군%진원
乳腺肿瘤%Ras相关C3肉毒菌毒物底物1%缺氧诱导因子1α%免疫组织化学
乳腺腫瘤%Ras相關C3肉毒菌毒物底物1%缺氧誘導因子1α%免疫組織化學
유선종류%Ras상관C3육독균독물저물1%결양유도인자1α%면역조직화학
Breast neoplasms%Ras-related C3 botulinum toxin substrate 1%Hypoxia-inducible factor-1α%Immunohistochemistry
目的 探讨Ras相关C3肉毒菌毒物底物1(Rac-1)与缺氧诱导因子1α(HIF-1α)在乳腺癌中的表达及其与临床分期、组织学分级及激素受体状态的关系.方法 乳腺癌标本共139例,应用免疫组织化学方法检测乳腺癌组织中Rac-1和HIF-1α蛋白的表达,并结合临床病理因素及激素受体状态进行统计学分析.结果 Rac-1、HIF-1α在乳腺癌组织中的阳性率分别为64.75%(90/139)和65.47%(91/139),二者均与TNM分期及组织学分级有关(均P<0.05),与年龄、性别、组织类型、月经状态无关(均P>0.05).Rac -1、HIF-1α在三阴性乳腺癌与非三阴性乳腺癌组织中表达差异无统计学意义(x 2=1.1229,x 2=0.1786,均P>0.05).在乳腺癌组织中,Rac-1与HIF-1α的表达呈正相关(rs=0.414,P< 0.01).结论 Rac-1和HIF-1d在乳腺癌组织中的表达具有相关性,可能成为反映乳腺癌生物学行为的新型分子标志物,阻断二者之间的联系在乳腺癌的治疗中可能具有较高的临床意义.
目的 探討Ras相關C3肉毒菌毒物底物1(Rac-1)與缺氧誘導因子1α(HIF-1α)在乳腺癌中的錶達及其與臨床分期、組織學分級及激素受體狀態的關繫.方法 乳腺癌標本共139例,應用免疫組織化學方法檢測乳腺癌組織中Rac-1和HIF-1α蛋白的錶達,併結閤臨床病理因素及激素受體狀態進行統計學分析.結果 Rac-1、HIF-1α在乳腺癌組織中的暘性率分彆為64.75%(90/139)和65.47%(91/139),二者均與TNM分期及組織學分級有關(均P<0.05),與年齡、性彆、組織類型、月經狀態無關(均P>0.05).Rac -1、HIF-1α在三陰性乳腺癌與非三陰性乳腺癌組織中錶達差異無統計學意義(x 2=1.1229,x 2=0.1786,均P>0.05).在乳腺癌組織中,Rac-1與HIF-1α的錶達呈正相關(rs=0.414,P< 0.01).結論 Rac-1和HIF-1d在乳腺癌組織中的錶達具有相關性,可能成為反映乳腺癌生物學行為的新型分子標誌物,阻斷二者之間的聯繫在乳腺癌的治療中可能具有較高的臨床意義.
목적 탐토Ras상관C3육독균독물저물1(Rac-1)여결양유도인자1α(HIF-1α)재유선암중적표체급기여림상분기、조직학분급급격소수체상태적관계.방법 유선암표본공139례,응용면역조직화학방법검측유선암조직중Rac-1화HIF-1α단백적표체,병결합림상병리인소급격소수체상태진행통계학분석.결과 Rac-1、HIF-1α재유선암조직중적양성솔분별위64.75%(90/139)화65.47%(91/139),이자균여TNM분기급조직학분급유관(균P<0.05),여년령、성별、조직류형、월경상태무관(균P>0.05).Rac -1、HIF-1α재삼음성유선암여비삼음성유선암조직중표체차이무통계학의의(x 2=1.1229,x 2=0.1786,균P>0.05).재유선암조직중,Rac-1여HIF-1α적표체정정상관(rs=0.414,P< 0.01).결론 Rac-1화HIF-1d재유선암조직중적표체구유상관성,가능성위반영유선암생물학행위적신형분자표지물,조단이자지간적련계재유선암적치료중가능구유교고적림상의의.
Objective To explore the expression and clinical significance of Ras-related C3 botulinum toxin substrate 1 (Rac-1) protein and hypoxia-inducible factor 1α (HIF-1α) in breast cancer and their relationship with tumor stage, node metastasis status and hormone receptor status. Methods Immunohistochemical method was used to detect the expression of Rac-1 and HIF-1α protein in 139 specimens of breast cancer,combined with their clinical pathological characteristics and hormone receptor status for statistical analysis.Results The expression of Rac-1 and HIF-1α in breast cancer tissue were 64.75 % and 65.47 %,respectively.The levels were related with the stage of TNM and histological grade (P < 0.05,P < 0.01).There was no significant correlation between these two proteins' expression and the age of patient, primary pathological location, histologic type and menstruation status of breast cancer patients (P > 0.05). The expression of Rac-1 and HIF-1α had no statistical significance between triple negative breast cancer (TNBC)and non-triple negative breast cancer (NTNBC) patients (x2 =1.1229,x2 =0.1786,P > 0.05); The expression level of Rac-1 was positively correlated with HIF-1α in these breast cancer specimens (rs =0.414,P < 0.01).Conclusion The expression of Rac-1 is positively correlated with HIF-1α level in breast cancer. The relationship between Rac-1 and HIF-1α might be as a new important marker to estimate the invasion,metastasis extent and prognosis in breast cancer.Blocking the regulation between Rac-1 and HIF-1α might be a new treatment target in breast cancer.