中国临床神经外科杂志
中國臨床神經外科雜誌
중국림상신경외과잡지
CHINESE JOURNAL OF CLINICAL NEUROSURGERY
2009年
7期
415-417,421
,共4页
赵亚群%王永%杨辉%周敬安%俞建臣
趙亞群%王永%楊輝%週敬安%俞建臣
조아군%왕영%양휘%주경안%유건신
垂体腺瘤%侵袭性%半乳糖凝集素-3%Ki-67%表达
垂體腺瘤%侵襲性%半乳糖凝集素-3%Ki-67%錶達
수체선류%침습성%반유당응집소-3%Ki-67%표체
Pituitary adenomas%Invasiveness%Galectin-3,Ki-67%Expression
目的 探讨半乳糖凝集素-3(galectin-3)蛋白表达及Ki-67标记指数(Ki-67 LI)与垂体腺瘤侵袭性的关系.方法 运用免疫组化SP法检测50例标本中galectin-3蛋白的表达及Ki-67 LI,分析galectin-3蛋白的表达及Ki一67¨与垂体腺瘤侵袭性的内第三军医大学附属新桥医院神经外科(重庆,400037)在关系.结果 galectin-3蛋白表达局限于泌乳素(PRL)腺瘤、促肾上腺皮质激素(ACTH)腺瘤及部分多激素分泌型腺瘤,在其他类型垂体腺瘤中表达呈阴性;且galectin-3在上述类型侵袭性腺瘤中的表达水平(galectin-3计分为3.264±1.066)明显高于非侵袭性腺瘤(galectin-3计分为1.613±0.850)(P<0.01).Ki-67 LI在侵袭性组和非侵袭性组分别为2.7541±1.029和1.692±0.858,两组有显著性差异(P<0.01).在表达galectin-3蛋门的垂体腺瘤中其表达水平与Kj-67 LI之间存在正相关性(r=0.916,P<0.01).结论 在PRL、ACTH腺瘤及部分多激素分泌型腺瘤中,galectin-3蛋白的表达与Ki-67 LI呈明显正相关性,同时检测二者可以作为评价此类型垂体腺瘤侵袭性的重要参考指标之一.
目的 探討半乳糖凝集素-3(galectin-3)蛋白錶達及Ki-67標記指數(Ki-67 LI)與垂體腺瘤侵襲性的關繫.方法 運用免疫組化SP法檢測50例標本中galectin-3蛋白的錶達及Ki-67 LI,分析galectin-3蛋白的錶達及Ki一67¨與垂體腺瘤侵襲性的內第三軍醫大學附屬新橋醫院神經外科(重慶,400037)在關繫.結果 galectin-3蛋白錶達跼限于泌乳素(PRL)腺瘤、促腎上腺皮質激素(ACTH)腺瘤及部分多激素分泌型腺瘤,在其他類型垂體腺瘤中錶達呈陰性;且galectin-3在上述類型侵襲性腺瘤中的錶達水平(galectin-3計分為3.264±1.066)明顯高于非侵襲性腺瘤(galectin-3計分為1.613±0.850)(P<0.01).Ki-67 LI在侵襲性組和非侵襲性組分彆為2.7541±1.029和1.692±0.858,兩組有顯著性差異(P<0.01).在錶達galectin-3蛋門的垂體腺瘤中其錶達水平與Kj-67 LI之間存在正相關性(r=0.916,P<0.01).結論 在PRL、ACTH腺瘤及部分多激素分泌型腺瘤中,galectin-3蛋白的錶達與Ki-67 LI呈明顯正相關性,同時檢測二者可以作為評價此類型垂體腺瘤侵襲性的重要參攷指標之一.
목적 탐토반유당응집소-3(galectin-3)단백표체급Ki-67표기지수(Ki-67 LI)여수체선류침습성적관계.방법 운용면역조화SP법검측50례표본중galectin-3단백적표체급Ki-67 LI,분석galectin-3단백적표체급Ki일67¨여수체선류침습성적내제삼군의대학부속신교의원신경외과(중경,400037)재관계.결과 galectin-3단백표체국한우비유소(PRL)선류、촉신상선피질격소(ACTH)선류급부분다격소분비형선류,재기타류형수체선류중표체정음성;차galectin-3재상술류형침습성선류중적표체수평(galectin-3계분위3.264±1.066)명현고우비침습성선류(galectin-3계분위1.613±0.850)(P<0.01).Ki-67 LI재침습성조화비침습성조분별위2.7541±1.029화1.692±0.858,량조유현저성차이(P<0.01).재표체galectin-3단문적수체선류중기표체수평여Kj-67 LI지간존재정상관성(r=0.916,P<0.01).결론 재PRL、ACTH선류급부분다격소분비형선류중,galectin-3단백적표체여Ki-67 LI정명현정상관성,동시검측이자가이작위평개차류형수체선류침습성적중요삼고지표지일.
Objective To study the relationship of the invasiveness of the pituitary adenomas with the expression of galectin-3 and Ki-67 labeling index (LI). Methods The expression of galectin-3 and Ki-67 LI were detected by immunohistochemical technique in 50 samples of pituitary adenomas. The relationship of the invasiveness of th pituitary adenomas with the expression of galectin-3 and Ki-67 LI was analyzed. Results The expression levels of galectin-3 were significantly higher in prolactin (PRC), adrencontgicotropic hormone (ACTH) and multihormonal adenomas than those in the function-free adenomas, gonadotropin adenomas and growth hormone adenomas (P<0.01). The expression levels of galeetin-3 and Ki-67 LI were significantly higher in the invasive adenomas than those in the noninvasive adenomas (P<0.01). The expression of galectin-3 was positively related significantly to Ki-67 LI in PRL, ACTH and muhihormonal adenomas (P<0.01). Conclusions There is a significantly positive relationship between the expression of galectin-3 and Ki-67 LI in PRL, ACTH and muhihormonal adenomas. It is suggested that the expression of galectin-3 and Ki-67 LI are related to the invasiveness of the pituitary adenomas.
