CAJ | 학술논문

细胞衰老是细胞周期抑制的极端稳定状态,DNA损伤和癌基因活化均可导致细胞衰老.癌基因诱导性衰老被认为是防止肿瘤发生的重要屏障.最近发现,癌基因诱导性细胞衰老发生于肿瘤形成的早期阶段.在癌变前肿瘤病变中,有丰富的衰老肿瘤细胞,而在恶性肿瘤中则显得稀少.因此,衰老是恶变前肿瘤细胞的重要特征,将在癌症的早期诊断和预后方面彰显重要价值.
세포쇠로시세포주기억제적겁단은정상태,DNA손상화암기인활화균가도치세포쇠로.암기인유도성쇠로피인위시방지종류발생적중요병장.최근발현,암기인유도성세포쇠로발생우종류형성적조기계단.재암변전종류병변중,유봉부적쇠로종류세포,이재악성종류중칙현득희소.인차,쇠로시악변전종류세포적중요특정,장재암증적조기진단화예후방면창현중요개치.
Cellular senescence is an extremely stable form of cell cycle arrest and can be induced by DNA damage as well as oncogene activation. Oncogene-induced senescence is considered as an important barrier against the development of cancer.Several recent reports found that oncogene-induced senescence occurs in the early stages of cancer development.A large number of cells enter senescence in premalignant neoplastic lesions but much less cells do so in malignant tunors.So, senescence is a significant characteristic of premalignant tumor cells, therefore may have important diagnostic and/or prognostic values for management of cancer.