国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2009年
5期
272-275
,共4页
阻塞性睡眠呼吸暂停低通气综合征%代谢综合征%持续气道正压通气%Ghrelin
阻塞性睡眠呼吸暫停低通氣綜閤徵%代謝綜閤徵%持續氣道正壓通氣%Ghrelin
조새성수면호흡잠정저통기종합정%대사종합정%지속기도정압통기%Ghrelin
Obstructive sleep apnea-hypopnea syndrome%Metabolic syndrome%Continuous positive airway pressure%Ghrelin
目的 探讨阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea-hypopnea syndrome,OSAHS)合并代谢综合征(metabolic syndrome,MS)患者血浆ghrelin水平的变化及意义.方法 测定OSAHS、MS、OSAHS合并MS患者及正常对照组血浆ghrelin水平并比较其间差异,测定持续气道正压通气治疗前及治疗1周后ghrelin水平并比较其变化.结果 各组血浆ghrelin值分别为:轻度单纯OSAHS组(7例)(56.41±3.99)ng/L,中度单纯OSAHS组(10例)(55.09±5.25)ng/L,重度单纯OSAHS组(19例)(56.28±4.99)ng/L;正常对照组(20名)(63.93±5.27)ng/L;单纯MS组(20例)(55.91±5.37)ng/L;OSAHS合并MS组(14例)治疗前(52.74±2.68)ng/L.治疗后(54.34±3.11)ng/L.单纯OSAHS组、OSAHS合并MS组及单纯MS组的血浆ghrelin水平都较正常对照组降低(P<0.05),OSAHS组间及与单纯MS组间ghrelin水平差异无统计学意义,OSAHS合并MS组持续气道正压通气治疗前后ghrelin水平差异无统计学意义.结论 OSAHS及MS都是一种前炎症状态,其血浆中ghrelin水平均低于正常,ghrelin可能在OSAHS及MS的发生、发展中有重要作用.
目的 探討阻塞性睡眠呼吸暫停低通氣綜閤徵(obstructive sleep apnea-hypopnea syndrome,OSAHS)閤併代謝綜閤徵(metabolic syndrome,MS)患者血漿ghrelin水平的變化及意義.方法 測定OSAHS、MS、OSAHS閤併MS患者及正常對照組血漿ghrelin水平併比較其間差異,測定持續氣道正壓通氣治療前及治療1週後ghrelin水平併比較其變化.結果 各組血漿ghrelin值分彆為:輕度單純OSAHS組(7例)(56.41±3.99)ng/L,中度單純OSAHS組(10例)(55.09±5.25)ng/L,重度單純OSAHS組(19例)(56.28±4.99)ng/L;正常對照組(20名)(63.93±5.27)ng/L;單純MS組(20例)(55.91±5.37)ng/L;OSAHS閤併MS組(14例)治療前(52.74±2.68)ng/L.治療後(54.34±3.11)ng/L.單純OSAHS組、OSAHS閤併MS組及單純MS組的血漿ghrelin水平都較正常對照組降低(P<0.05),OSAHS組間及與單純MS組間ghrelin水平差異無統計學意義,OSAHS閤併MS組持續氣道正壓通氣治療前後ghrelin水平差異無統計學意義.結論 OSAHS及MS都是一種前炎癥狀態,其血漿中ghrelin水平均低于正常,ghrelin可能在OSAHS及MS的髮生、髮展中有重要作用.
목적 탐토조새성수면호흡잠정저통기종합정(obstructive sleep apnea-hypopnea syndrome,OSAHS)합병대사종합정(metabolic syndrome,MS)환자혈장ghrelin수평적변화급의의.방법 측정OSAHS、MS、OSAHS합병MS환자급정상대조조혈장ghrelin수평병비교기간차이,측정지속기도정압통기치료전급치료1주후ghrelin수평병비교기변화.결과 각조혈장ghrelin치분별위:경도단순OSAHS조(7례)(56.41±3.99)ng/L,중도단순OSAHS조(10례)(55.09±5.25)ng/L,중도단순OSAHS조(19례)(56.28±4.99)ng/L;정상대조조(20명)(63.93±5.27)ng/L;단순MS조(20례)(55.91±5.37)ng/L;OSAHS합병MS조(14례)치료전(52.74±2.68)ng/L.치료후(54.34±3.11)ng/L.단순OSAHS조、OSAHS합병MS조급단순MS조적혈장ghrelin수평도교정상대조조강저(P<0.05),OSAHS조간급여단순MS조간ghrelin수평차이무통계학의의,OSAHS합병MS조지속기도정압통기치료전후ghrelin수평차이무통계학의의.결론 OSAHS급MS도시일충전염증상태,기혈장중ghrelin수평균저우정상,ghrelin가능재OSAHS급MS적발생、발전중유중요작용.
Objective To investigate the significance of ghrelin level in obstructive sleep apnea-hypopnea syndrome (OSAHS) associated with metabolic syndrome (MS). Methods Ghrelin level was measured in OSAHS group, MS group, OSAHS plus MS group,control group, before and after continuous positive airway pressure(CPAP) treatment in OSAHS plus MS group respectively,and differences between each two groups were investigated. Results Ghrelin levels in mild OSAHS group(7cases) [(56.41±3.99) ng/L], moderate OSA HS group( 10 cases) [(55.09±5.25 ) ng/L], sever OSAHS group( 19 cases) [ ( 56.28 ±4.99) ng/LJ,MS group (20 cases)[(55.91±5.37) ng/L],OSAHS plus MS group (14 cases)I(52. 74± 2.68) ng/L] were lower than that in control group (20 cases)[(55.91 ± 5.37) ng/L] respectively( P 0.05),but there was no significant difference between the OSAHS group and MS group. Baseline plasma ghrelin levels in OSAHS plus MS group (14 cases)I(52. 744±2.68) ng/L] did not change significantly from the level [(54.34 ±3.11) ng/L] after one week of CPAP treatment. Conclusions OSAHS and MS are both pro-inflammatory states,and their plasma ghrelin levels are both lower than that of control group. Ghrelin may play a role in the development of OSAHS and MS.
