CAJ | 학술논문

糖尿病肾脏疾病(DKD)的发病机制十分复杂,其发生、发展是在遗传背景基础上多因素综合作用的结果,目前认为高血糖是引起DKD进展的主要原因,炎性反应和氧化应激加速了DKD的病理过程.腺苷酸活化蛋白激酶(AMPK)是“细胞能量调节器”,在调节糖、脂代谢方面起重要作用.AMPK作为一个重要的信号通路,通过参与细胞蛋白质合成、机体炎性反应和氧化应激等过程,在延缓DKD的发生、发展中发挥了重要作用.
당뇨병신장질병(DKD)적발병궤제십분복잡,기발생、발전시재유전배경기출상다인소종합작용적결과,목전인위고혈당시인기DKD진전적주요원인,염성반응화양화응격가속료DKD적병리과정.선감산활화단백격매(AMPK)시“세포능량조절기”,재조절당、지대사방면기중요작용.AMPK작위일개중요적신호통로,통과삼여세포단백질합성、궤체염성반응화양화응격등과정,재연완DKD적발생、발전중발휘료중요작용.
The pathogenesis of-diabetic nephropathy is complex,many factors contribute to the occurrence and development of DKD on the genetic background.Hyperglycemia is currendy considered the main reason of DKD.Inflammatory response and oxidative stress accelerate the pathological process of DKD.AMP-activated protein kinase(AMPK) is a "cellular energy regulator",which plays an important role in the regulation of glucose and lipid metabolism.In addition,as a signaling pathway,AMPK plays an important role in delaying the occurrence and development of DKD by participating in protein synthesis,inflammatory response and oxidative stress process.