CAJ | 학술논문

炎症是机体对外界刺激的一种防御性反应,通常情况下对机体是有益的,但其失调则可导致对机体自身组织的攻击而产生病变,因此炎症反应必定要受到机体内外环境的严密调控以保证其正常进行.正常情况下,炎症刺激如病原微生物感染可激活细胞内的多条信号通路,而丝裂原激活的丝裂原激活的蛋白激酶(MAPK)信号传导通路是其中最为重要的一种.双特异性磷酸酶1(DUSP1,又称为MKP1)可特异性地抑制MAPK家族成员p38、JNK和ERK等的活性,是细胞中介导炎症反应的自限以及促进炎症消退的重要调控因子.
염증시궤체대외계자격적일충방어성반응,통상정황하대궤체시유익적,단기실조칙가도치대궤체자신조직적공격이산생병변,인차염증반응필정요수도궤체내외배경적엄밀조공이보증기정상진행.정상정황하,염증자격여병원미생물감염가격활세포내적다조신호통로,이사렬원격활적사렬원격활적단백격매(MAPK)신호전도통로시기중최위중요적일충.쌍특이성린산매1(DUSP1,우칭위MKP1)가특이성지억제MAPK가족성원p38、JNK화ERK등적활성,시세포중개도염증반응적자한이급촉진염증소퇴적중요조공인자.
The inflammatory response,triggered by the external stimuli,is a kind of defensive reactions.It is beneficial in most situations.However,dysregulated inflammatory responses can cause severe tissue damage and the death of the organism.Therefore,inflammatory responses must be tightly regualted to maintain normal body homeostasis.Under normal circumstances,inflammatory stimulators such as pathogenic microorganisms can activate multiple signal transduction pathways.MAPK pathway is one of the most important pathways in innate immune cells.Dual specificity phosphatase-1 ( DUSP1,also called MKP1 ) can specifically inhibit the activity of p38,JNK and ERK,the major members of MAPK family.It plays an important role in the selflimitation of inflammatory responses and the resolution of inflammation.