中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2011年
9期
749-751
,共3页
马莉敏%夏芳珍%朱惠%陈奕%余娇%李影%李艳香%张惠新%乔洁%陆颖理
馬莉敏%夏芳珍%硃惠%陳奕%餘嬌%李影%李豔香%張惠新%喬潔%陸穎理
마리민%하방진%주혜%진혁%여교%리영%리염향%장혜신%교길%륙영리
胰升糖素%生长抑素%C肽%糖尿病,2型
胰升糖素%生長抑素%C肽%糖尿病,2型
이승당소%생장억소%C태%당뇨병,2형
Glucagon%Somatostatin%C-peptide%Diabetes mellitus,type 2
检测60例2型糖尿病患者和34名正常对照者空腹及口服75 g葡萄糖2h后胰升糖素、生长抑素(SS)和C肽水平。结果显示，与对照组比较，糖尿病组空腹胰升糖素、SS及糖负荷后2 h SS明显降低（均P＜0.01），空腹及2 h C肽明显升高（均P＜0.01）。两组糖负荷后2 h激素水平均显著高于空腹(均P＜0.01)，与对照组比较，糖尿病组胰升糖素（1.40±0.48对1.20±0.30,P＜0.05）和SS(2.79±2.17对1.14±0.22，P＜0.01)餐后增加倍数更高，C肽增加倍数较低（3.58±3.10对8.33±6.99，P＜0.01）；两组空腹胰升糖素水平与SS呈正相关（均P＜0.01）。以上结果提示，2型糖尿病患者不仅β细胞功能紊乱，尚存在α、δ细胞相关激素紊乱。
檢測60例2型糖尿病患者和34名正常對照者空腹及口服75 g葡萄糖2h後胰升糖素、生長抑素(SS)和C肽水平。結果顯示，與對照組比較，糖尿病組空腹胰升糖素、SS及糖負荷後2 h SS明顯降低（均P＜0.01），空腹及2 h C肽明顯升高（均P＜0.01）。兩組糖負荷後2 h激素水平均顯著高于空腹(均P＜0.01)，與對照組比較，糖尿病組胰升糖素（1.40±0.48對1.20±0.30,P＜0.05）和SS(2.79±2.17對1.14±0.22，P＜0.01)餐後增加倍數更高，C肽增加倍數較低（3.58±3.10對8.33±6.99，P＜0.01）；兩組空腹胰升糖素水平與SS呈正相關（均P＜0.01）。以上結果提示，2型糖尿病患者不僅β細胞功能紊亂，尚存在α、δ細胞相關激素紊亂。
검측60례2형당뇨병환자화34명정상대조자공복급구복75 g포도당2h후이승당소、생장억소(SS)화C태수평。결과현시，여대조조비교，당뇨병조공복이승당소、SS급당부하후2 h SS명현강저（균P＜0.01），공복급2 h C태명현승고（균P＜0.01）。량조당부하후2 h격소수평균현저고우공복(균P＜0.01)，여대조조비교，당뇨병조이승당소（1.40±0.48대1.20±0.30,P＜0.05）화SS(2.79±2.17대1.14±0.22，P＜0.01)찬후증가배수경고，C태증가배수교저（3.58±3.10대8.33±6.99，P＜0.01）；량조공복이승당소수평여SS정정상관（균P＜0.01）。이상결과제시，2형당뇨병환자불부β세포공능문란，상존재α、δ세포상관격소문란。
The fasting and 2 h levels of glucagon, somatostatin ( SS), and C-peptide during 75 g oral glucose tolerance test in 60 patients with type 2 diabetes and 34 normal subjects were determined. Compared with control group, the fasting levels of glucagon and SS and 2 h levels of SS after glucose loading significantly decreased,while the fasting and 2 h levels of C-peptide increased in diabetes group. The 2 h levels of these hormones were significantly higher than the fasting levels in two groups. Compared with control group, the increased folds of glucagon ( 1.40±0.48 vs 1.20±0. 30, P＜0. 05 ) and SS( 2.79±2. 17 vs 1.14±0. 22, P＜0. 01 ) levels after glucose loading were higher and that of C-peptide level ( 3.58 ±3. 10 vs 8. 33 ± 6. 99, P＜0. 01 ) was lower in diabetes group. The levels of fasting glucagon were positively correlated with that of fasting SS in two groups( both P＜0. 01 ). These results suggest that disturbance exists in hormones from α and δ cells besides the dysfunction of β cells in patients with type 2 diabetes.
