中华神经医学杂志
中華神經醫學雜誌
중화신경의학잡지
CHINESE JOURNAL OF NEUROMEDICINE
2009年
8期
817-819
,共3页
星形细胞瘤%血管内皮生长因子%Ki-67
星形細胞瘤%血管內皮生長因子%Ki-67
성형세포류%혈관내피생장인자%Ki-67
Astroeytoma%Vascular endothelial growth factor%Ki-67
目的 研究血管内皮生长因子(VEGF)和Ki-67抗原在人脑星形细胞瘤中的表达及二者的相关性.方法 应用免疫组化S-P法检测30例正常脑组织和60例人脑星形细胞瘤(Ⅰ～Ⅱ级28例,Ⅲ级20例,Ⅳ级12例)中VEGF和Ki-67的表达.结果 VEGF和Ki-67在正常脑组织中均不表达,而在各级别的人脑星形细胞瘤中均有表达,差异有统计学意义(P<0.05).VEGF和Ki-67的表达在高级别星形细胞瘤中均明显高于低级别星形细胞瘤,差异均有统计学意义(P<0.05),且VEGF与Ki-67的表达呈正相关(r=0.310,P<0.05).结论 VEGF和Ki-67的表达可为人脑星形细胞瘤的恶性程度和临床病理分级提供重要的依据.
目的 研究血管內皮生長因子(VEGF)和Ki-67抗原在人腦星形細胞瘤中的錶達及二者的相關性.方法 應用免疫組化S-P法檢測30例正常腦組織和60例人腦星形細胞瘤(Ⅰ～Ⅱ級28例,Ⅲ級20例,Ⅳ級12例)中VEGF和Ki-67的錶達.結果 VEGF和Ki-67在正常腦組織中均不錶達,而在各級彆的人腦星形細胞瘤中均有錶達,差異有統計學意義(P<0.05).VEGF和Ki-67的錶達在高級彆星形細胞瘤中均明顯高于低級彆星形細胞瘤,差異均有統計學意義(P<0.05),且VEGF與Ki-67的錶達呈正相關(r=0.310,P<0.05).結論 VEGF和Ki-67的錶達可為人腦星形細胞瘤的噁性程度和臨床病理分級提供重要的依據.
목적 연구혈관내피생장인자(VEGF)화Ki-67항원재인뇌성형세포류중적표체급이자적상관성.방법 응용면역조화S-P법검측30례정상뇌조직화60례인뇌성형세포류(Ⅰ～Ⅱ급28례,Ⅲ급20례,Ⅳ급12례)중VEGF화Ki-67적표체.결과 VEGF화Ki-67재정상뇌조직중균불표체,이재각급별적인뇌성형세포류중균유표체,차이유통계학의의(P<0.05).VEGF화Ki-67적표체재고급별성형세포류중균명현고우저급별성형세포류,차이균유통계학의의(P<0.05),차VEGF여Ki-67적표체정정상관(r=0.310,P<0.05).결론 VEGF화Ki-67적표체가위인뇌성형세포류적악성정도화림상병리분급제공중요적의거.
Objective To study the expressions of vascular endothelial growth factor (VEGF) and Ki-67 antigen and their correlation in human brain astrocytorna. Methods Immunohistochemistry with SP method was employed to detect the expressions of VEGF and Ki-67 in 60 human brain astrocytoma tissue (grade Ⅰ-Ⅱ 28 cases, grade Ⅲ 20 cases, grade Ⅳ 12 cases) and 30 normal tissues adjacent to the tumors. Results VEGF and Ki-67 were not expressed in the normal brain tissues adjacent to the astrocytoma, but their expressions were detected in all the astroeytoma tissues of different grades (P<0.05). High-grade astrocytomas showed significantly higher VEGF and Ki-67 expression than low-grade astrocytomas (P<0.05), and a positive correlation was noted between VEGF and Ki-67 expressions (r=0.310, P<0.05). Conclusion VEGF and Ki-67 expressions can provide important evidence for evaluating the malignancy and clinicopathologieal grading of human astrocytoma.
