CAJ | 학술논문

背景与目的:恶性肿瘤细胞表达共刺激分子B7-H1来抑制T细胞功能,逃避机体的抗肿瘤免疫反应.本研究通过检测人胰腺癌组织中B7-H1蛋白的表达,探讨其与胰腺癌患者临床病理指标及预后之间的关系.方法:采用免疫组化法检测B7-H1在40例胰腺癌组织和10例癌旁正常胰腺组织中的表达情况,用卡方检验或确切概率法分析B7-H1的表达与胰腺癌患者各临床病理指标以及生存时间的关系.结果:40例胰腺癌组织中B7-H1阳性率为45.00%(18/40).高于癌旁正常胰腺组织(P<0.05);B7-H1表达与患者肿瘤分期、术前CA19-9有关(P<0.05).多因素Cox同归模型显示,B7-H1表达是胰腺癌患者无复发生存期、总生存期的独立危险因素.结论:人胰腺癌组织中存在B7-H1蛋白表达,B7-H1表达与胰腺癌患荇的预后有关.
배경여목적:악성종류세포표체공자격분자B7-H1래억제T세포공능,도피궤체적항종류면역반응.본연구통과검측인이선암조직중B7-H1단백적표체,탐토기여이선암환자림상병리지표급예후지간적관계.방법:채용면역조화법검측B7-H1재40례이선암조직화10례암방정상이선조직중적표체정황,용잡방검험혹학절개솔법분석B7-H1적표체여이선암환자각림상병리지표이급생존시간적관계.결과:40례이선암조직중B7-H1양성솔위45.00%(18/40).고우암방정상이선조직(P<0.05);B7-H1표체여환자종류분기、술전CA19-9유관(P<0.05).다인소Cox동귀모형현시,B7-H1표체시이선암환자무복발생존기、총생존기적독립위험인소.결론:인이선암조직중존재B7-H1단백표체,B7-H1표체여이선암환행적예후유관.
Background and Objective:B7-H1,a member of B7 family,is expressed in tumor cells and has emerged as an important immune modulator capable of suppressing host immunity by inhibiting T cells function.This study was to probe into the correlation between the expression level of B7-H1 protein in pancreatic carcinoma tissues and clinicopathological characteristics and prognosis.Methods:The expression of B7-H1 was measured in 40 cases of pancreatic carcinoma tissues and 10 cases of normal corresponding paracaroinoma tissues by immunohistochemistry.The relationship between the expression level of B7-H1 and clinicopathological characteristics and survival was analyzed.Results:The positive rate of B7-H1 was significantly higher in the tumor tissues [45.00%(18/40)]than in the normal corresponding paracarcinoma tissues[0(0/10)](P<0.05);moreover,B7-H1 expression was significantly associated with the staging of tumor and preoperative serum CA19-9 level(P<0.05).The multivariate cox proportional hazards regression analysis of prognostic factors for overall survival and relapse-free survivalshowed that the expression of B7-H1 was an independent factor for poor prognosis.Conclusion: B7-H1 protein was expressed in human pancreatic carcinoma tissues,and was associated with the prognosis.