安徽农业科学
安徽農業科學
안휘농업과학
JOURNAL OF ANHUI AGRICULTURAL SCIENCES
2010年
3期
1258-1260
,共3页
TLR21%TLRs%斑马鱼
TLR21%TLRs%斑馬魚
TLR21%TLRs%반마어
TLR21%TLRs%Zebrafish
[目的]研究斑马鱼TLR21受体家族的作用.[方法]用各种纯组分刺激斑马鱼,研究斑马鱼TLR21受体家族(zTLR21.1、zTLR21.3、zTLR21.4)的表达量变化,推测它们的功能.[结果]zTLR21.1对于LTA刺激无反应,对于LPS、ployI:C和Glucan刺激都有上调反应.zTLR21.3和zTLR21.4对于LPS、LTA和ployI:C刺激均无反应,对于Glucan刺激有明显上调变化.[结论]zTLR21.1可能是一种能够识别大部分抗原的模式识别受体.zTLR21.3和zTLR21.4的功能很类似,可能都是酵母的特异识别受体.
[目的]研究斑馬魚TLR21受體傢族的作用.[方法]用各種純組分刺激斑馬魚,研究斑馬魚TLR21受體傢族(zTLR21.1、zTLR21.3、zTLR21.4)的錶達量變化,推測它們的功能.[結果]zTLR21.1對于LTA刺激無反應,對于LPS、ployI:C和Glucan刺激都有上調反應.zTLR21.3和zTLR21.4對于LPS、LTA和ployI:C刺激均無反應,對于Glucan刺激有明顯上調變化.[結論]zTLR21.1可能是一種能夠識彆大部分抗原的模式識彆受體.zTLR21.3和zTLR21.4的功能很類似,可能都是酵母的特異識彆受體.
[목적]연구반마어TLR21수체가족적작용.[방법]용각충순조분자격반마어,연구반마어TLR21수체가족(zTLR21.1、zTLR21.3、zTLR21.4)적표체량변화,추측타문적공능.[결과]zTLR21.1대우LTA자격무반응,대우LPS、ployI:C화Glucan자격도유상조반응.zTLR21.3화zTLR21.4대우LPS、LTA화ployI:C자격균무반응,대우Glucan자격유명현상조변화.[결론]zTLR21.1가능시일충능구식별대부분항원적모식식별수체.zTLR21.3화zTLR21.4적공능흔유사,가능도시효모적특이식별수체.
[Objective] The aim was to study the function of zebrafish TLR21 receptors. [Method] Zebrafish was stimulated with different pure components, then the variation of zebrafish TLR21 receptors (zTLR21.1, zTLR21.3, zTLR21.4) in expression was studied to speculate the function. [Result] The results showed that LPS, ployI:C and Glucan could up-regulate the expression of zTLR21.1 but not LTA. In addition, Glucan could obviously up-regulate the expression of zTLR21.3 and zTLR21.4 but not LPS, LTA and ployI:C. [Conclusion] zTLR21.1 might be a receptor to recognize most of microorganisms, functions of zTLR21.3 and zTLR21.4 are similar, they might be specific receptors of yeast.
