CAJ | 학술논문

分别以嵌段共聚物(聚乳酸-单甲氧基聚乙二醇,分子量比为40 000:2 000)和非嵌段共聚物(聚乳酸-聚羟乙酸,分子量均为40 000,摩尔比分别为75:25、50:50)作为载体材料,采用乳化-液中干燥法制备包载氟维司群的微球.大鼠单剂量(50 mg/kg)皮下注射3种氟维司群微球,采用LC-MS/MS法测定血药浓度,计算药动学参数.结果表明,使用嵌段共聚物制备的微球,药-时曲线较平稳,释放效果较好.
분별이감단공취물(취유산-단갑양기취을이순,분자량비위40 000:2 000)화비감단공취물(취유산-취간을산,분자량균위40 000,마이비분별위75:25、50:50)작위재체재료,채용유화-액중간조법제비포재불유사군적미구.대서단제량(50 mg/kg)피하주사3충불유사군미구,채용LC-MS/MS법측정혈약농도,계산약동학삼수.결과표명,사용감단공취물제비적미구,약-시곡선교평은,석방효과교호.
Fulvestrant microspheres entrapped by PLA-block-mPEG copolymer (molecular weight ratio 40 000 : 2 000) and two kind of PLGA (molecule weight 40 000, molar ratio 75 : 25 and 50 : 50) were prepared with emulsion in liquid drying method. Three kinds of fulvestrant microspheres were given subcutaneously to rats respectively, with single dosage of 50 mg/kg. The drug concentrations were determined by LC-MS/MS. The results showed that the fulvestrant microsphere prepared by PLA-block-mPEG copolymer had a smooth concentration-time chart. The releasing effect of the PLA-block-mPEG microsphere was better than that prepared by two kind of PLGA.