CAJ | 학술논문

Objective To investigate the effect of micronized fenofibrate on vascular endothelial function in patients with hypertriglyceridemia.Methods Using high-resolution ultrasound, we measured flow- and nitroglycerin-induced dilatation of the brachial artery in 30 patients with hypertriglyceridemia before and after treatment with micronized fenofibrate at a dose of 200 mg once daily for 4 weeks. Simultaneously, both serum lipid and plasma endothelin (ET) levels were determined.Results After micronized fenofibrate therapy, serum triglyceride (TG) levels decreased significantly (P<0.05). Plasma ET levels also decreased markedly [(82.66±15.46) μg/L vs. (106.22±19.16) μg/L, P<0.001]. Flow-induced vasodilatation was much improved (11.0%±9.0% vs 2.7%±2.0%, P<0.01). However, no significant changes in vasodilatation occurred in response to nitroglycerin (16.2%±6.0% vs 15.0%±5.0%, P>0.05) in patients with hypertriglyceridemia. Conclusions Micronized fenofibrate can improve impaired endothelium-dependent vasodilatation in patients with hypertriglyceridemia. Improving endothelial function may also be the mechanism responsible for the beneficial effects of micronized fenofibrate.