CAJ | 학술논문

目的评价5-氨基酮戊酸光动力疗法(ALA-PDT)与咪喹莫特联合治疗基底细胞癌的疗效.方法将38例基底细胞癌患者随机分为两组,各19例.治疗组采用ALA-PDT与咪喹莫特联合治疗,对照组单用ALA-PDT.所有患者随访一年,观察两组疗效和复发率.结果治疗组患者痊愈率为94.74%(18/19),复发率为5.26%(1/19);对照组痊愈率为68.42%(13/19),复发率为31.58%(6/19).两组痊愈率及复发率差异有统计学意义(x2=4.37,P<0.05).结论 ALA-PDT联合咪喹莫特治疗基底细胞癌在疗效及复发率方面均明显优于单用ALA-PDT.
목적 평개5-안기동무산광동력요법(ALA-PDT)여미규막특연합치료기저세포암적료효.방법 장38례기저세포암환자수궤분위량조,각19례.치료조채용ALA-PDT여미규막특연합치료,대조조단용ALA-PDT.소유환자수방일년,관찰량조료효화복발솔.결과 치료조환자전유솔위94.74%(18/19),복발솔위5.26%(1/19);대조조전유솔위68.42%(13/19),복발솔위31.58%(6/19).량조전유솔급복발솔차이유통계학의의(x2=4.37,P<0.05).결론 ALA-PDT연합미규막특치료기저세포암재료효급복발솔방면균명현우우단용ALA-PDT.
Objective To evaluate the clinical efficacy of 5-aminolevulinic acid-photodynamic therapy (ALA-PDT) combined with imiquimod for basal cell carcinoma( BCC).Methods 38 patients with BCC were randomly divided into two groups.ALA-PDT plus imiquimod were given in the treatment group (19 patients) , and the control group(19 patients) were treated with only ALA-PDT.All patients were followed for one year,and the efficacy and relapse rate were observed.Results The cure rate and the recurrence rate of the treatment group was 94.74% ( 18/19) and 5.26% (1/19) .however,those of the control group was 68.42% (13/19) and 31.58% (6/19).There was a statistical difference in the cure rate and recurrence rate between the two groups(x2 =4.37,P <0.05).Conclusion The efficacy and relapse rate of ALA-PDT combined with imiquimod was much better than those of ALA-PDT only in treatment of BCC.