中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2011年
13期
1780-1781
,共2页
胆结石%白细胞介素6%白细胞介素8%肿瘤坏死因子α%T淋巴细胞亚群
膽結石%白細胞介素6%白細胞介素8%腫瘤壞死因子α%T淋巴細胞亞群
담결석%백세포개소6%백세포개소8%종류배사인자α%T림파세포아군
Cholelithiasis%Interleukin-6%Interleukin-8%Tumor necrosis factor-alpha%T-lymphocyte subsets
目的 观察胆结石患者治疗前后多项血清白介素及T淋巴细胞亚群水平的变化.方法 选择72例胆结石患者作为观察组,另选同期健康体检的健康人30例作为对照组,观察组于术前和术后5 d检测血清白介素水平和T淋巴细胞亚群水平.结果 观察组术前血清IL-6、IL-8和TNF-α水平分别为(61.5±4.8)ng/L、(246.2±15.3)ng/L和(1.79±0.72)mg/L,均显著高于术后和健康对照组(均P＜0.05),而术后血清IL-6、IL-8和TNF-α水平与健康对照组比较均差异无统计学意义(均P＞0.05);观察组术前CD3+、CD4+和CD8+T细胞的比例分别为(0.53±0.06)%、(0.28±0.05)%和(0.21±0.04)%,均显著低于术后和健康对照组(均P＜0.05),而术后CD3+、CD4+和CD8+T细胞的比例和健康对照组比较均差异无统计学意义(均P＞0.05).结论 胆结石患者存在明显的血清IL-6、IL-8和TNF-α以及CD3+、CD4+和CD8+T细胞水平异常,手术去除胆结石不但能消除炎症,而且有助于患者免疫功能的恢复.
目的 觀察膽結石患者治療前後多項血清白介素及T淋巴細胞亞群水平的變化.方法 選擇72例膽結石患者作為觀察組,另選同期健康體檢的健康人30例作為對照組,觀察組于術前和術後5 d檢測血清白介素水平和T淋巴細胞亞群水平.結果 觀察組術前血清IL-6、IL-8和TNF-α水平分彆為(61.5±4.8)ng/L、(246.2±15.3)ng/L和(1.79±0.72)mg/L,均顯著高于術後和健康對照組(均P＜0.05),而術後血清IL-6、IL-8和TNF-α水平與健康對照組比較均差異無統計學意義(均P＞0.05);觀察組術前CD3+、CD4+和CD8+T細胞的比例分彆為(0.53±0.06)%、(0.28±0.05)%和(0.21±0.04)%,均顯著低于術後和健康對照組(均P＜0.05),而術後CD3+、CD4+和CD8+T細胞的比例和健康對照組比較均差異無統計學意義(均P＞0.05).結論 膽結石患者存在明顯的血清IL-6、IL-8和TNF-α以及CD3+、CD4+和CD8+T細胞水平異常,手術去除膽結石不但能消除炎癥,而且有助于患者免疫功能的恢複.
목적 관찰담결석환자치료전후다항혈청백개소급T림파세포아군수평적변화.방법 선택72례담결석환자작위관찰조,령선동기건강체검적건강인30례작위대조조,관찰조우술전화술후5 d검측혈청백개소수평화T림파세포아군수평.결과 관찰조술전혈청IL-6、IL-8화TNF-α수평분별위(61.5±4.8)ng/L、(246.2±15.3)ng/L화(1.79±0.72)mg/L,균현저고우술후화건강대조조(균P＜0.05),이술후혈청IL-6、IL-8화TNF-α수평여건강대조조비교균차이무통계학의의(균P＞0.05);관찰조술전CD3+、CD4+화CD8+T세포적비례분별위(0.53±0.06)%、(0.28±0.05)%화(0.21±0.04)%,균현저저우술후화건강대조조(균P＜0.05),이술후CD3+、CD4+화CD8+T세포적비례화건강대조조비교균차이무통계학의의(균P＞0.05).결론 담결석환자존재명현적혈청IL-6、IL-8화TNF-α이급CD3+、CD4+화CD8+T세포수평이상,수술거제담결석불단능소제염증,이차유조우환자면역공능적회복.
Objective To observe the changes of serum interleukin and T lymphocyte subsets levels in patients with gallstones before and after treatment. Methods 72 patients with gallstones were treated as research subjects and 30 cases with normal physical examination as the control group,the serum interleukin and T lymphocyte subsets levels of observation group were detected before and after surgery. Results The preoperative serum IL-6, IL-8 and TNF-α levels of observation group were(61.5 ±4. 8) ng/L, (246. 2 ±15.3)ng/L and(1.79 ±0.72)mg/L respectively which were significantly higher than postoperative and control group,the difference was statistically significant (P ＜ 0. 05 ) , while there was no significant difference between postoperative and normal control group ( P ＞ 0.05); The preoperative CD3+ , CD4+ and CD8+ T cells ratio of observation group were (0. 53 ± 0. 06) % , (0. 28 ±0.05)% and(0.21±0.04)% respectively which were significantly higher than postoperative and control group,the difference was statistically significant(P ＜ 0.05) , while there was no significant difference between postoperative and normal control group(P＞0.05). Conclusion Patients with gallstone had obvious abnormal serum IL-6, IL-8, TNF-α,CD3+ ,CD4+ and CD8+ T cells levels,surgery could not only eliminate inflammation,but also help the recovery of immune function in patients.
