CAJ | 학술논문

聚乳酸-羟基乙酸共聚物(PLGA)包裹药物制成微球制剂是近年来药物输送体系的研究热点,但是PLGA包囊药物尤其是蛋白多肽类变性失活问题是研究的难点.改进生产工艺特别是使用添加剂可提高微球中包载药物的稳定性.综述了PLGA微球制备及释放过程中不同添加剂的作用特别是稳定蛋白药物的作用.
취유산-간기을산공취물(PLGA)포과약물제성미구제제시근년래약물수송체계적연구열점,단시PLGA포낭약물우기시단백다태류변성실활문제시연구적난점.개진생산공예특별시사용첨가제가제고미구중포재약물적은정성.종술료PLGA미구제비급석방과정중불동첨가제적작용특별시은정단백약물적작용.
Microspheres made of poly-lactic-co-glycolic acid (PLGA) have been frequently proposed as drug delivery systems.A very significant challenge in the development of controlled PLGA releasing systems is the instability of drugs especially therapeutic peptides and proteins.Additional approaches,particularly the use of additives,are needed to optimize PLGA delivery of drugs.This article reviews the effects of additives,especially the effects of stabilizing protein during the preparation of PLGA microsphere and the sustained drug releasing processes.