CAJ | 학술논문

目的了解淋巴瘤患者血清中抗磷脂抗体( APL)的阳性率及水平,探讨抗磷脂抗体淋巴瘤患者中的临床和免疫学意义.方法应用ELISA法检测129例淋巴瘤、46例系统性红斑狼疮(SLE)、38例类风湿关节炎(RA)、24例原发性干燥综合征(pSS)及58名健康对照的血清中的抗心磷脂抗体IgG/M/A和抗β2糖蛋白Ⅰ抗体IgG/M/A,分析其与淋巴瘤患者一般情况、临床特点、免疫学表型及血栓事件的关系.结果 (1)抗磷脂抗体在淋巴瘤患者血清中的阳性率为40.3％ (52/129),其中抗心磷脂抗体阳性率11.6％ (15/129),抗β2糖蛋白Ⅰ抗体阳性率32.6％ (42/129).抗心磷脂抗体及抗β2糖蛋白Ⅰ抗体在淋巴瘤患者血清中的水平及阳性率均明显高于健康对照组(P＜0.05),4与SLE、RA、pSS组的抗体水平相仿(P＞0.05).(2)T或NK/T细胞淋巴瘤中抗磷脂抗体阳性率明显高于B细胞淋巴瘤(P＜0.05).(3)抗磷脂抗体阳性与阴性的淋巴瘤患者中血栓事件的发生率差异无统计学意义.(4)抗磷脂抗体阳性淋巴瘤患者的无事件生存时间短于抗磷脂抗体阴性者.结论抗磷脂抗体在淋巴瘤患者血清中的阳性率及抗体水平均较健康人群明显升高,与SLE等自身免疫病患者无明显差别.抗磷脂抗体多见于T或NK/T细胞来源的非霍奇金淋巴瘤.抗磷脂抗体可能与淋巴瘤患者的无事件生存时间有关.
목적 료해림파류환자혈청중항린지항체( APL)적양성솔급수평,탐토항린지항체림파류환자중적림상화면역학의의.방법 응용ELISA법검측129례림파류、46례계통성홍반랑창(SLE)、38례류풍습관절염(RA)、24례원발성간조종합정(pSS)급58명건강대조적혈청중적항심린지항체IgG/M/A화항β2당단백Ⅰ항체IgG/M/A,분석기여림파류환자일반정황、림상특점、면역학표형급혈전사건적관계.결과 (1)항린지항체재림파류환자혈청중적양성솔위40.3％ (52/129),기중항심린지항체양성솔11.6％ (15/129),항β2당단백Ⅰ항체양성솔32.6％ (42/129).항심린지항체급항β2당단백Ⅰ항체재림파류환자혈청중적수평급양성솔균명현고우건강대조조(P＜0.05),4여SLE、RA、pSS조적항체수평상방(P＞0.05).(2)T혹NK/T세포림파류중항린지항체양성솔명현고우B세포림파류(P＜0.05).(3)항린지항체양성여음성적림파류환자중혈전사건적발생솔차이무통계학의의.(4)항린지항체양성림파류환자적무사건생존시간단우항린지항체음성자.결론 항린지항체재림파류환자혈청중적양성솔급항체수평균교건강인군명현승고,여SLE등자신면역병환자무명현차별.항린지항체다견우T혹NK/T세포래원적비곽기금림파류.항린지항체가능여림파류환자적무사건생존시간유관.
Objective To explore the prevalence,clinical and prognostic significance of anticardiolipin (aCL) IgG/M/A antibodies and anti-β2-glycoprotein Ⅰ (2-GPI) IgG/M/A antibodies in patients with lymphoma.Methods ACL IgG/M/A antibodies and anti-β2-GPl IgG/M/A antibodies were determined by enzyme-linked immunosorbent assay (ELISA) in 129 lymphoma patients,46 SIE patients,38 rheumatoid arthritis (RA) patients,24 primary Sj(o)gren's syndrome (pSS) patients and 58 healthy controls.Laboratory and clinical features (thrombosis,event-free-survival time,etc.) were analyzed retrospectively from the clinical database.Results ( 1 ) Elevated APL level was found in 52/129 lymphoma patients (40.3％):aCL IgG/M/A antibodies in 11.6％ (15/129) and anti-β2-GPl IgG/M/A antibodies in 32.6％ (42/129) of lymphoma patients.There were significant differences between the prevalence and level of APL in lymphoma patients and healthy controls.But no difference was found between the lymphoma patients and SLE,RA or pSS patients.(2) APL was correlated with lymphoma dervied from T or NK/T cells ( P ＜ 0.05 ).( 3 ) No difference was found between the incidence of thrombosis in lymphoma patients with or without APL.(4) A strong negative correlation was found between the elevated APL and the eventfree survival.Conclusion APL is elevated in 40.3％ of lymphoma patients.And it is significantly higher than that in healthy controls and similar with that in SLE,RA or pSS patients.APL is correlated with lymphoma cell origin and shortened event-free survival.