基质金属蛋白酶7在非小细胞肺癌中表达的临床意义
기질금속단백매7재비소세포폐암중표체적림상의의
Clinical significance expression of MMP-7 in patients with primary non-small cell lung cancer
  • 万方数据
    肿瘤研究与临床 종류연구여림상
    CANCER RESEARCH AND CLINIC
    2008年 11期 743-744,748 ,共3页

    韩福才%单彬彬%程小珍%朱海波%郭伟%郭沁香%田瑞芬%苏文忠

    한복재%단빈빈%정소진%주해파%곽위%곽심향%전서분%소문충

    癌,非小细胞肺%基质金属蛋白酶 癌,非小細胞肺%基質金屬蛋白酶
    암,비소세포폐%기질금속단백매
    Carcinoma,Non-small cell lung%Matrix metalloproteinases 7
    目的 研究基质金属蛋白酶7(MMP-7)在非小细胞肺癌(NSCLC)组织中的表达,探讨MMP-7与NSCLC患者临床病理特征的关系.方法 用RT-PCR技术检测20名健康人外周血标本及60例晚期NSCLC患者的外周血标本,凝胶图像分析仪分析MMP-7结果.结果 健康人外周血中的MMP-7(30.000)显著低于NSCLC患者外周血中的MMP-7(41.231)(P<0.05);MMP-7在NSCLC组织中的表达与患者性别、病理类型、肿瘤瘤体大小无关(P>0.05);与肺癌组织分化程度呈负相关(P<0.05),与临床分期呈正相关(P<0.05).结论 研究表明MMP-7是判断NSCLC侵袭转移生物学行为的一个好的标志物.
    목적 연구기질금속단백매7(MMP-7)재비소세포폐암(NSCLC)조직중적표체,탐토MMP-7여NSCLC환자림상병리특정적관계.방법 용RT-PCR기술검측20명건강인외주혈표본급60례만기NSCLC환자적외주혈표본,응효도상분석의분석MMP-7결과.결과 건강인외주혈중적MMP-7(30.000)현저저우NSCLC환자외주혈중적MMP-7(41.231)(P<0.05);MMP-7재NSCLC조직중적표체여환자성별、병리류형、종류류체대소무관(P>0.05);여폐암조직분화정도정부상관(P<0.05),여림상분기정정상관(P<0.05).결론 연구표명MMP-7시판단NSCLC침습전이생물학행위적일개호적표지물.
    Objective To study the relationship between expression of matrix metalloproteinases-7 (MMP-7) and clinicopathological characteristics in patients with primary non-smaU cell lung cancer(NSCLC). Methods MMP-7 in 20 normal people and 60 advanced NSCLC patiens were detected with reverse-transcription-polymerase-chain-reaction. Gelatum image analysator analyzed the result. Results The amount of MMP-7 was less in normal people (30.000) than in NSCLC patients(41.231) significantly(P<0.05); the level of MMP-7 was no correlated with gender, age, pathology pattern, tumor size, was inverse correlation with differentiation, and was positive correlation with clinical stages(P <0.05). Conclusion The level of MMP-7 is closely correlated with tissue differentiation and clinical stages of NSCLC, which may serve as a parameter for determining tumor invasion and metastatic.
    원문보기 원문다운로드 사이트로이동
저자의 최근 논문