CAJ | 학술논문

目的观察氟比洛芬酯联合吗啡镇痛对胃癌患者术后吗啡用药量及肠功能恢复的影响.方法 40例择期全麻下行胃癌根治术患者,随机分为氟比洛芬酯组和吗啡组,每组20例,分别于术前0.5 h静注氟比洛芬酯或安慰剂英脱利匹特.术后距第一次给药6 h再次静注氟比洛芬酯或英脱利匹特.两组患者术后均行患者自控静脉镇痛(PCIA).记录两组患者术后12、24、36、48 h的VAS和舒适评分(BCS),记录术后吗啡用量以及术后第一次肛门排气的时间.结果两组VAS和BCS评分在各相应时间点差异无统计学意义.术后1～12 h氟比洛芬酯组吗啡用量为(16.99±3.51)mg,明显低于吗啡组的(25.09±4.63)mg(P<0.01).氟比洛芬酯组患者术后第一次肛门排气的时间为(69.05±11.20)h,短于吗啡组的(78.05±12.94)h(P<0.05).结论围术期使用氟比洛芬酯可减少胃癌患者术后静脉镇痛的吗啡用量,促进肠功能恢复.
목적 관찰불비락분지연합마배진통대위암환자술후마배용약량급장공능회복적영향.방법 40례택기전마하행위암근치술환자,수궤분위불비락분지조화마배조,매조20례,분별우술전0.5 h정주불비락분지혹안위제영탈리필특.술후거제일차급약6 h재차정주불비락분지혹영탈리필특.량조환자술후균행환자자공정맥진통(PCIA).기록량조환자술후12、24、36、48 h적VAS화서괄평분(BCS),기록술후마배용량이급술후제일차항문배기적시간.결과 량조VAS화BCS평분재각상응시간점차이무통계학의의.술후1～12 h불비락분지조마배용량위(16.99±3.51)mg,명현저우마배조적(25.09±4.63)mg(P<0.01).불비락분지조환자술후제일차항문배기적시간위(69.05±11.20)h,단우마배조적(78.05±12.94)h(P<0.05).결론 위술기사용불비락분지가감소위암환자술후정맥진통적마배용량,촉진장공능회복.
Objective To observe the effects of postoperative analgesia with flurbiprofen axetil and morphine on morphine requirements and intestinal function recovery in patients after gastric cancer surgeries. Methods Forty patients undergoing elective gastric cancer surgery under general anesthesia were randomly allocated into flurbiprofen axetil group(A) and morphine group(B) with 20 cases each. The patients in group A and B received intravenous flurbiprofen axetil and intralipid 0. 5 h before surgery, respectivel,which were repeaded at 6 h later. All patients received patient-controlled intravenous analgesia (PCIA) postoperatively. The scores of VAS and BCS, and the requirements of morphine were recorded at 12, 24, 36, and 48 h after operation. The time of first flatus after operation was recorded. Results The scores of VAS and BCS were not significantly different between the two groups at all time points. The requirements of morphine in group A was significantly lower than that in groupB[(16.99±3.51)mg vs. (25.09±4. 63) mg](P<0.01). The time of first flatus was earlier in group A than that in group B(P<0.05). Conclusion Perioperative administration of flurbiprofen axetil may reduce morphine requirements during PCIA and facilitate intestinal function recovery in patients after gastric cancer surgery.