CAJ | 학술논문

间充质干细胞( mesenchymal stem cell,MSC)在体内外可被诱导分化为多种上皮细胞,如肺泡上皮、肾小管上皮和角膜上皮细胞等,表达上皮细胞特异性标志.MSC回输体内后,可有效修复损伤的肺上皮细胞组织,缓解炎症损伤,减轻肾小管细胞损伤、减少肾间质炎症细胞浸润,促进肾小管上皮细胞再生,并抑制细胞凋亡；也可在载体上利用MSC构建生物角膜,进行眼表修复,MSC本身还能表达角化生长因子等多种因子促进角膜缘干细胞增殖.另外,MSC还可以向胰腺导管上皮细胞、子宫内膜上皮细胞、生精上皮细胞、人视网膜色素上皮细胞等分化.MSC在临床治疗上皮细胞损伤类疾病中展现出其巨大的应用潜能,为上皮类疾病的治疗提供了新的方法.
간충질간세포( mesenchymal stem cell,MSC)재체내외가피유도분화위다충상피세포,여폐포상피、신소관상피화각막상피세포등,표체상피세포특이성표지.MSC회수체내후,가유효수복손상적폐상피세포조직,완해염증손상,감경신소관세포손상、감소신간질염증세포침윤,촉진신소관상피세포재생,병억제세포조망；야가재재체상이용MSC구건생물각막,진행안표수복,MSC본신환능표체각화생장인자등다충인자촉진각막연간세포증식.령외,MSC환가이향이선도관상피세포、자궁내막상피세포、생정상피세포、인시망막색소상피세포등분화.MSC재림상치료상피세포손상류질병중전현출기거대적응용잠능,위상피류질병적치료제공료신적방법.
Mesenchymal stem cells (MSC) is able to differentiate into a variety of epithelial cells,such as alveolar epithelium,tubular epithelium and corneal epithelial cells in vivo and in vitro under the given condition.After transfusion,MSC can effectively repair the injured lung epithelial cells,and relieve inflammation.MSC can also repair the renal tubular cell damage by reducing renal interstitial infiltration of inflammatory cells,promoting regeneration of renal tubular epithelial cells and inhibiting of apoptosis; Biological cornea can be available constructed by using MSC,which can availably repair the injured ocular surface.In the other hands,MSC can express keratinocyte growth factors and other cytokines,promoting limbal stem cell proliferation.In addition,MSC can also differentiate into pancreatic ductal epithelial cells,endometrial epithelial cells,spermatogenic epithelium and human retinal pigment epithelium.MSC has great application potential in epithelial diseases,and provide a good and effective choice in treatment of some epithelial diseases.