中华实验眼科杂志
中華實驗眼科雜誌
중화실험안과잡지
CHINESE JOURNAL OF EXPERIMENTAL OPHTHALMOLOGY
2012年
7期
646-649
,共4页
自发荧光%中心性浆液性脉络膜视网膜病变%脂褐素%黑色素%眼底检查
自髮熒光%中心性漿液性脈絡膜視網膜病變%脂褐素%黑色素%眼底檢查
자발형광%중심성장액성맥락막시망막병변%지갈소%흑색소%안저검사
Autofluorescence%Central serous chorioretinopathy%Lipofuscin%Melanin%Fundus examination
背景 眼底自发荧光(AF)成像是一种新的非侵人性眼底荧光检测技术,可利用共焦激光扫描检眼镜获得两种眼底AF,包括脂褐素相关的AF(FAF)和黑色素相关的近红外AF(NIA).目的 探讨中心性浆液性脉络膜视网膜病变(CSC)患者眼底FAF和NIA两种AF特征.方法 对CSC患者23例28眼进行FAF、NIA和荧光素眼底血管造影(FFA)检查,其中急性期CSC 15例17眼,慢性迁延性CSC 8例11眼.结果 急性期CSC患者FFA荧光素渗漏点AF改变有3种特征:(1)AF增强,包括FAF增强2眼,占11.76％；NIA增强4眼,占23.53％.(2)无AF,包括FAF 10眼,占58.82％；NIA 13眼,占76.47％.(3)AF正常,包括FAF 5眼,占29.42％；NIA 0眼.视网膜浆液性脱离区AF改变有2种特征:(1)AF减弱,包括FAF减弱12眼,占70.59％；NIA减弱10眼,占58.82％.(2)AF增强,包括FAF增强5眼,占29.41％；NIA增强7眼,占41.18％.慢性迁延性CSC患者AF像中,FFA检查视网膜色素上皮(RPE)渗漏点位置表现为无AF,部分无AF点在相应位置的FFA像未见RPE渗漏点,而N1A像中所见的无AF点常常多于FAF.慢性CSC视网膜浆液性脱离区常表现为颗粒样无AF、AF增强及AF减弱等多种AF改变并存的复合病灶,并且AF像显示的异常荧光范围常常大于对应的FFA显示的异常荧光区.结论 AF技术为研究CSC提供了一种活体观察RPE细胞代谢和功能改变的手段.
揹景 眼底自髮熒光(AF)成像是一種新的非侵人性眼底熒光檢測技術,可利用共焦激光掃描檢眼鏡穫得兩種眼底AF,包括脂褐素相關的AF(FAF)和黑色素相關的近紅外AF(NIA).目的 探討中心性漿液性脈絡膜視網膜病變(CSC)患者眼底FAF和NIA兩種AF特徵.方法 對CSC患者23例28眼進行FAF、NIA和熒光素眼底血管造影(FFA)檢查,其中急性期CSC 15例17眼,慢性遷延性CSC 8例11眼.結果 急性期CSC患者FFA熒光素滲漏點AF改變有3種特徵:(1)AF增彊,包括FAF增彊2眼,佔11.76％；NIA增彊4眼,佔23.53％.(2)無AF,包括FAF 10眼,佔58.82％；NIA 13眼,佔76.47％.(3)AF正常,包括FAF 5眼,佔29.42％；NIA 0眼.視網膜漿液性脫離區AF改變有2種特徵:(1)AF減弱,包括FAF減弱12眼,佔70.59％；NIA減弱10眼,佔58.82％.(2)AF增彊,包括FAF增彊5眼,佔29.41％；NIA增彊7眼,佔41.18％.慢性遷延性CSC患者AF像中,FFA檢查視網膜色素上皮(RPE)滲漏點位置錶現為無AF,部分無AF點在相應位置的FFA像未見RPE滲漏點,而N1A像中所見的無AF點常常多于FAF.慢性CSC視網膜漿液性脫離區常錶現為顆粒樣無AF、AF增彊及AF減弱等多種AF改變併存的複閤病竈,併且AF像顯示的異常熒光範圍常常大于對應的FFA顯示的異常熒光區.結論 AF技術為研究CSC提供瞭一種活體觀察RPE細胞代謝和功能改變的手段.
배경 안저자발형광(AF)성상시일충신적비침인성안저형광검측기술,가이용공초격광소묘검안경획득량충안저AF,포괄지갈소상관적AF(FAF)화흑색소상관적근홍외AF(NIA).목적 탐토중심성장액성맥락막시망막병변(CSC)환자안저FAF화NIA량충AF특정.방법 대CSC환자23례28안진행FAF、NIA화형광소안저혈관조영(FFA)검사,기중급성기CSC 15례17안,만성천연성CSC 8례11안.결과 급성기CSC환자FFA형광소삼루점AF개변유3충특정:(1)AF증강,포괄FAF증강2안,점11.76％；NIA증강4안,점23.53％.(2)무AF,포괄FAF 10안,점58.82％；NIA 13안,점76.47％.(3)AF정상,포괄FAF 5안,점29.42％；NIA 0안.시망막장액성탈리구AF개변유2충특정:(1)AF감약,포괄FAF감약12안,점70.59％；NIA감약10안,점58.82％.(2)AF증강,포괄FAF증강5안,점29.41％；NIA증강7안,점41.18％.만성천연성CSC환자AF상중,FFA검사시망막색소상피(RPE)삼루점위치표현위무AF,부분무AF점재상응위치적FFA상미견RPE삼루점,이N1A상중소견적무AF점상상다우FAF.만성CSC시망막장액성탈리구상표현위과립양무AF、AF증강급AF감약등다충AF개변병존적복합병조,병차AF상현시적이상형광범위상상대우대응적FFA현시적이상형광구.결론 AF기술위연구CSC제공료일충활체관찰RPE세포대사화공능개변적수단.
Background Auto-fluorescence(AF)imaging is a new non-invasive fundus examining technology.It is now playing an increasingly important role in the diagnosis of retinal diseases.Using a confocal Scanning Laser Ophthalmoscope microscope(cSLO),two types of AF can be obtained:melanin-related near-infrared fundus auto-fluorescence(NIA)and lipofuscin-related fundus auto-fluorescence(FAF).Objective The purpose of this study was to compare the outcome between NIA and FAF in patients with central serous chorioretinopathy (CSC).Methods FAF,NIA imaging and fundus fluorescein angiography(FFA)were performed on 28 eyes of 23 subjects using a cLSO.AF images were evaluated and compared with angiographic findings.Written informed consent was obtained before the initiation of this study.Results In 17 eyes of 15 cases with acute CSC,the leakage points on the FFA image showed three kinds of AF patterns:(1)hyper-AF,including FAF hyper-AF in 2 eyes(11.76％)and NIA hyper-AF in 4 eyes(23.53％).(2)Non-AF,including FAF non-AF in 10 eyes(58.82％)and NIA non-AF in 13 eyes(76.47％).(3)Normal AF,including normal AF of FAF in 5 eyes(29.42％).The AF in the retinal serous detachment area showed two kinds of characteristics:(1)hypo-AF,including 12 eyes(70.59％)with FAF hypo-AF and 10 eyes(58.82％)with NIA hypo-AF.(2)hyper-AF,including 5 eyes(29.41％)with FAF hyper-AF and 7 eyes (41.18％)with NIA hyper-AF.In 11 eyes of 8 cases with chronic CSC,the leakage on the FFA also showed an absence of AF.However,AF-absent areas also partly appeared in the non-leakage area of FFA.In NIA,the non-AF areas were often more visible than that in FAF.Serous detachment areas in chronic CSC usually displayed multiple AF forms,including granular-like non-AF,hyper-AF and hypo-AF,and the abnormal AF areas were often greater than that of the corresponding abnormal fluorescent area in FFA.Conclusions AF can be used to detect the functional status and metabolic activity of RPE in CSC eyes.
