中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2012年
9期
820-822
,共3页
王益%陈绪才%朱迎春%王国成
王益%陳緒纔%硃迎春%王國成
왕익%진서재%주영춘%왕국성
皮层下非痴呆血管性认知障碍%蒙特利尔认知评估表%筛查
皮層下非癡呆血管性認知障礙%矇特利爾認知評估錶%篩查
피층하비치태혈관성인지장애%몽특리이인지평고표%사사
Subcortcial vascular cognitive impairment-no dementia%Montreal cognitive assessment%Screening
目的 探索蒙特利尔认知评估量表(MoCA)筛查皮层下非痴呆血管性认知障碍(VaCIND-S)汉族老年人的可行性.方法 共入组75名汉族老年人,包括VaCIND-S患者40例,正常对照组35例,进行MoCA、简易精神状态量表(MMSE)等检查,研究VaCIND-S的神经心理学特征,使用ROC曲线分析其灵敏度和特异度.结果 两组患者在年龄、性别、教育程度上差异均无显著性(P＞0.05),使用MoCA发现VaCIND-S患者在记忆功能、视空间、执行功能、注意力、语言功能、定向力得分[分别为(0.43±1.01)分,(2.21±1.19)分,(2.11±1.13)分,(4.66±1.48)分,(4.42±1.31)分,(4.86±1.12)分]均低于正常对照组得分[分别为(2.93±1.36)分,(3.29±1.06)分,(3.53±0.93)分,(5.94±0.24)分,(5.44±0.71)分,(5.80±0.48)分],差异有显著性(P＜0.05).MoCA在VaCIND-S的筛查中较MMSE灵敏,在截断值为23.5分时有较高的灵敏度和特异度,分别为0.971和0.789.结论 MoCA是一个可靠的VaCIND-S筛选工具,且较MMSE敏感,尚需要进一步在大规模及不同种族人群中进行研究.
目的 探索矇特利爾認知評估量錶(MoCA)篩查皮層下非癡呆血管性認知障礙(VaCIND-S)漢族老年人的可行性.方法 共入組75名漢族老年人,包括VaCIND-S患者40例,正常對照組35例,進行MoCA、簡易精神狀態量錶(MMSE)等檢查,研究VaCIND-S的神經心理學特徵,使用ROC麯線分析其靈敏度和特異度.結果 兩組患者在年齡、性彆、教育程度上差異均無顯著性(P＞0.05),使用MoCA髮現VaCIND-S患者在記憶功能、視空間、執行功能、註意力、語言功能、定嚮力得分[分彆為(0.43±1.01)分,(2.21±1.19)分,(2.11±1.13)分,(4.66±1.48)分,(4.42±1.31)分,(4.86±1.12)分]均低于正常對照組得分[分彆為(2.93±1.36)分,(3.29±1.06)分,(3.53±0.93)分,(5.94±0.24)分,(5.44±0.71)分,(5.80±0.48)分],差異有顯著性(P＜0.05).MoCA在VaCIND-S的篩查中較MMSE靈敏,在截斷值為23.5分時有較高的靈敏度和特異度,分彆為0.971和0.789.結論 MoCA是一箇可靠的VaCIND-S篩選工具,且較MMSE敏感,尚需要進一步在大規模及不同種族人群中進行研究.
목적 탐색몽특리이인지평고량표(MoCA)사사피층하비치태혈관성인지장애(VaCIND-S)한족노년인적가행성.방법 공입조75명한족노년인,포괄VaCIND-S환자40례,정상대조조35례,진행MoCA、간역정신상태량표(MMSE)등검사,연구VaCIND-S적신경심이학특정,사용ROC곡선분석기령민도화특이도.결과 량조환자재년령、성별、교육정도상차이균무현저성(P＞0.05),사용MoCA발현VaCIND-S환자재기억공능、시공간、집행공능、주의력、어언공능、정향력득분[분별위(0.43±1.01)분,(2.21±1.19)분,(2.11±1.13)분,(4.66±1.48)분,(4.42±1.31)분,(4.86±1.12)분]균저우정상대조조득분[분별위(2.93±1.36)분,(3.29±1.06)분,(3.53±0.93)분,(5.94±0.24)분,(5.44±0.71)분,(5.80±0.48)분],차이유현저성(P＜0.05).MoCA재VaCIND-S적사사중교MMSE령민,재절단치위23.5분시유교고적령민도화특이도,분별위0.971화0.789.결론 MoCA시일개가고적VaCIND-S사선공구,차교MMSE민감,상수요진일보재대규모급불동충족인군중진행연구.
Objective To explore feasibility study of the Montreal cognitive assessment (MoCA) in detecting subcortcial vascular cognitive impairment-no dementia(VaCIND-S).Methods Seventy-five Chinese Han were assessed by the MoCA and MMSE.40 met criteria for VaCIND -S and 35 were considered cognitively normal.ROC curve analyses were performed to determine optimal sensitivity and specificity.Results No differences were found between groups on age,gender,education degrees.According to their MoCA scores,cognitive impairments including memory,visuospatial,executive function,attention,language,and orientation sub-scores in VaCIND-S ( (0.43 ± 1.01),(2.21 ± 1.19),(2.11 ± 1.13),(4.66 ± 1.48),(4.42 ±1.31),(4.86 ± 1.12)) significantly decreased compared with those in controls( (2.93 ± 1.36),(3.29 ± 1.06),(3.53 ±0.93),(5.94 ±0.24),(5.44 ± 0.71 ),(5.80 ± 0.48 ) ) (P ＜ 0.05 ).The MMSE scale was insensitive to cognitive impairment as compared with MoCA scale.Using cut-off score of 23.5,the MoCA exhibited excellent sensitivity (0.971 ) and specificity (0.789).Conclusion MoCA is a more sensitive instrument than the MMSE for the detection of VaCIND-S and warrants further investigation regarding its applicability in large and varying ethnic population.
