CAJ | 학술논문

目的探讨全身照射及半导体实时剂量监测方法在造血干细胞移植中应用的安全性和临床疗效.方法采用6 MV X线对57例需造血干细胞移植的患者行半坐立姿或侧卧式两野或四野前后平行对穿野单次或分次照射,并在照射中使用6个半导体探头对患者不同部位进行实时剂量监测,根据监测结果采用不同厚度的铅皮调整人体中平面受照剂量的均匀性.结果接受分次照射的41例患者疗后均有轻度和中度恶心、呕吐、腮腺肿胀等症状,但均能耐受,经对症治疗后好转,顺利完成造血干细胞的移植,无一发生间质性肺炎.实时监测也表明,患者全身照射剂量均匀性符合临床治疗要求.结论采用半导体探测器实时剂量监测与半坐立姿或侧卧式前后平行对穿照射技术是一种安全、有效的全身照射方法 .
목적 탐토전신조사급반도체실시제량감측방법 재조혈간세포이식중응용적안전성화림상료효.방법 채용6 MV X선대57례수조혈간세포이식적환자행반좌립자혹측와식량야혹사야전후평행대천야단차혹분차조사,병재조사중사용6개반도체탐두대환자불동부위진행실시제량감측,근거감측결과 채용불동후도적연피조정인체중평면수조제량적균균성.결과 접수분차조사적41례환자료후균유경도화중도악심、구토、시선종창등증상,단균능내수,경대증치료후호전,순리완성조혈간세포적이식,무일발생간질성폐염.실시감측야표명,환자전신조사제량균균성부합림상치료요구.결론 채용반도체탐측기실시제량감측여반좌립자혹측와식전후평행대천조사기술시일충안전、유효적전신조사방법 .
Objective To investigate the safety and clinical outcome of total body irradiation (TBI) and the real-time in vivo dosimetry with semiconductor dosimeter in hematogenous stem cell transplantation (HSCT). Methods Fifty-seven patients requiring HSCT were treated with TBI. The TBI was given with the semi-sitting or standing position or lateralcumbent posture, using 6 MV X-ray beams and opposed parallel fields technique (two or four fields, AP/PA fields) in a single fraction or multiple fractions. The real-time in vivo dosimetry was performed with six diodes positioned on the surface of patients to adjust the dose homo-geneity of the midplane using the different thickness lead sheets. Results Mild to moderate nausea, vomi-ting and swollen parotid occurred in 41 patients after TBI, which were relieved after allopathy therapy. No radiation-induced interstitial pneumonia was observed. All patients fulfilled the HSCT. The homogeneity of relative dose (normalize to umbilicus dose) in the different positions accorded with the requirement of the prescription dose. Conclusions The opposed parallel radiation, with the semi-sitting or standing positions or lateralcumbent posture, combined with the real-time in vivo dosimetry with semiconductor dosimeter is an effective and safe technique for TBI.