CAJ | 학술논문

目的探讨脑源性神经营养因子(BDNF)基因多态性与双相障碍的关联性.方法以228例双相障碍患者和362名正常对照者为研究对象,通过TaqMan探针单核甘酸多态性(SNP)基因分型技术对BDNF基因及基因上游10 kb 区域的标签SNP rs6265和rs11030101进行基因分型,比较各组间基因型、等位基因及联合基因型分布频率.结果双相障碍患者与正常对照的SNP rs6265和rs11030101基因型、等位基因及联合基因型分布频率比较差异无统计学意义;男女分层、不同临床类型以及不同发病年龄的双相障碍患者与正常对照的基因型、联合基因型之间比较差异均无统计学意义.结论研究未发现在中国汉族人群中脑源性神经营养因子基因多态性SNP rs6265和rs11030101与双相障碍有关.
목적 탐토뇌원성신경영양인자(BDNF)기인다태성여쌍상장애적관련성.방법 이228례쌍상장애환자화362명정상대조자위연구대상,통과TaqMan탐침단핵감산다태성(SNP)기인분형기술대BDNF기인급기인상유10 kb 구역적표첨SNP rs6265화rs11030101진행기인분형,비교각조간기인형、등위기인급연합기인형분포빈솔.결과 쌍상장애환자여정상대조적SNP rs6265화rs11030101기인형、등위기인급연합기인형분포빈솔비교차이무통계학의의;남녀분층、불동림상류형이급불동발병년령적쌍상장애환자여정상대조적기인형、연합기인형지간비교차이균무통계학의의.결론 연구미발현재중국한족인군중뇌원성신경영양인자기인다태성SNP rs6265화rs11030101여쌍상장애유관.
Objective To investigate the association between brain-derived neurotrophic factor (BDNF) gene polymorphism and bipolar disorder. Methods Single nucleotide polymorphisms rs6265 and rs11030101 in BDNF gene were detected and compared between 228 patients with bipolar disorder and 361 healthy controls. Results The genotypes, alleles and combinative genotype of BDNF gene single nucleotide polymorphism rs6265 and rs11030101 did not show significant differences between two groups. There were also no significant differences in genotypes and combinative genotypes between diagnostic subtypes, genders and on-set age of bipolar disorder and controls. Conclusion This study did not found that BDNF gene single nucleotide polymorphism rs6265 and rs11030101 are associated with bipolar disorders.