中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2011年
9期
612-615
,共4页
侯任%张炜旸%刘丽艳%卢剑%张为远
侯任%張煒旸%劉麗豔%盧劍%張為遠
후임%장위양%류려염%로검%장위원
孤啡肽%子宫腺肌病%痛经
孤啡肽%子宮腺肌病%痛經
고배태%자궁선기병%통경
Nociceptin%Adenomyosis%Dysmenorrhea
目的 研究孤啡肽在子宫腺肌病患者组织中的表达与患者痛经程度的关系.方法 收集吉林大学第二附属医院妇产科2007年12月至2008年6月,年龄41～52岁行全子宫切除术的子宫标本共55例,分为病例组(子宫腺肌病组)34例和对照组(子宫肌瘤组)21例,采用免疫组织化学方法检测病例组的在位内膜、异位内膜及对照组正常子宫内膜及肌层组织中孤啡肽的表达,并初步探讨孤啡肽表达与患者痛经关系的临床意义.结果 孤啡肽在病例组病灶及在位内膜组织中表达的计分分别为7.2±1.6及7.1±1.7,对照组在肌层及内膜组织中表达的计分分别为2.6±1.2及2.7±2.0,P＜0.05;孤啡肽在病例组痛经组病灶及在位内膜组织中表达计分为7.5±1.5,7.4±1.5,在无痛经组病灶及在位内膜组织中表达的计分分别为5.1±1.2,5.0±1.2,P＜0.05;孤啡肽的表达在病例组重度痛经组肌层及在位内膜组织表达最高计分分别为8.5±1.2,8.4±1.3,无痛经组计分分别为5.1±1.2,5.0±1.2,轻度痛经组计分分别为6.9±1.4,6.8±1.4,后两者比较差异无统计学意义(P＞0.05),中度痛经、轻度痛经及无痛经组在位内膜及肌层组织中的表达逐渐降低.结论 孤啡肽在子宫腺肌病中的高表达可能是引起痛经的因素之一;患者的痛经程度与在位内膜的孤啡肽表达呈正相关,与病灶组织的孤啡肽表达也呈正相关;动态检测在位内膜中孤啡肽的表达,以监测子宫腺肌病的发展变化.
目的 研究孤啡肽在子宮腺肌病患者組織中的錶達與患者痛經程度的關繫.方法 收集吉林大學第二附屬醫院婦產科2007年12月至2008年6月,年齡41～52歲行全子宮切除術的子宮標本共55例,分為病例組(子宮腺肌病組)34例和對照組(子宮肌瘤組)21例,採用免疫組織化學方法檢測病例組的在位內膜、異位內膜及對照組正常子宮內膜及肌層組織中孤啡肽的錶達,併初步探討孤啡肽錶達與患者痛經關繫的臨床意義.結果 孤啡肽在病例組病竈及在位內膜組織中錶達的計分分彆為7.2±1.6及7.1±1.7,對照組在肌層及內膜組織中錶達的計分分彆為2.6±1.2及2.7±2.0,P＜0.05;孤啡肽在病例組痛經組病竈及在位內膜組織中錶達計分為7.5±1.5,7.4±1.5,在無痛經組病竈及在位內膜組織中錶達的計分分彆為5.1±1.2,5.0±1.2,P＜0.05;孤啡肽的錶達在病例組重度痛經組肌層及在位內膜組織錶達最高計分分彆為8.5±1.2,8.4±1.3,無痛經組計分分彆為5.1±1.2,5.0±1.2,輕度痛經組計分分彆為6.9±1.4,6.8±1.4,後兩者比較差異無統計學意義(P＞0.05),中度痛經、輕度痛經及無痛經組在位內膜及肌層組織中的錶達逐漸降低.結論 孤啡肽在子宮腺肌病中的高錶達可能是引起痛經的因素之一;患者的痛經程度與在位內膜的孤啡肽錶達呈正相關,與病竈組織的孤啡肽錶達也呈正相關;動態檢測在位內膜中孤啡肽的錶達,以鑑測子宮腺肌病的髮展變化.
목적 연구고배태재자궁선기병환자조직중적표체여환자통경정도적관계.방법 수집길림대학제이부속의원부산과2007년12월지2008년6월,년령41～52세행전자궁절제술적자궁표본공55례,분위병례조(자궁선기병조)34례화대조조(자궁기류조)21례,채용면역조직화학방법검측병례조적재위내막、이위내막급대조조정상자궁내막급기층조직중고배태적표체,병초보탐토고배태표체여환자통경관계적림상의의.결과 고배태재병례조병조급재위내막조직중표체적계분분별위7.2±1.6급7.1±1.7,대조조재기층급내막조직중표체적계분분별위2.6±1.2급2.7±2.0,P＜0.05;고배태재병례조통경조병조급재위내막조직중표체계분위7.5±1.5,7.4±1.5,재무통경조병조급재위내막조직중표체적계분분별위5.1±1.2,5.0±1.2,P＜0.05;고배태적표체재병례조중도통경조기층급재위내막조직표체최고계분분별위8.5±1.2,8.4±1.3,무통경조계분분별위5.1±1.2,5.0±1.2,경도통경조계분분별위6.9±1.4,6.8±1.4,후량자비교차이무통계학의의(P＞0.05),중도통경、경도통경급무통경조재위내막급기층조직중적표체축점강저.결론 고배태재자궁선기병중적고표체가능시인기통경적인소지일;환자적통경정도여재위내막적고배태표체정정상관,여병조조직적고배태표체야정정상관;동태검측재위내막중고배태적표체,이감측자궁선기병적발전변화.
Objective To study the expression of nociceptin in adenomyosis tissue and understand its relationship with the severity of dysmenorrhea. Methods The myometrial specimens were collected from 55 patients undergoing hysterectomy at our hospital during December 2007 and June 2008. Their mean age was 41 -52 years old. There were 34 adenomyosis patients in case group and 21 other patients in control group. Immunohistochemical staining was employed to detect nociceptin in eutopic endometrium and ectopic endometrial tissues in case group and normal endometrium and myometrial tissues in control group. Results The expression of nociceptin was significantly higher in the eutopic endometrial tissue ( 7. 1 ± 1.7 ) of case group than those in endometrial(2.7±2.0 ) and myometrial tissues of control group ( P ＜ 0.05 ); The expression of nociceptin was higher in the eutopic endometrial tissue (7.4±1.5) of dysmenorrhea group than that of non-dysmenorrhea group ( 5.0 ± 1.2 ) in case group ( P ＜ 0.05 ); The expression of nociceptin in eutopic endometrium and myometrium was the highest in severe dysmenorrhea group ( 8.4 ±1.3 ). And the non-dysmenorrhea and mild dysmenorrheal groups had no significant differences [(5.0 ± 1.2 ) vs (6.8 ± 1.4)]. And it decreased gradually in moderate dysmenorrhea, mild dysmenorrhea and nondysmenorrhea groups. Conclusion A high expression of nociceptin in adenomyosis may be one of the casual factors of dysmenorrhea. The severity of dysmenorrhea is positively correlated with the expression of nociceptin in eutopic endometrial tissue in case group ( r = 0.515, P = 0.034) and ectopic endometrium tissue. And the endometrial expression of nociceptin may be monitored dynamically to track the development of adenomyosis.
