肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2012年
1期
69-71
,共3页
乳腺肿瘤%信号传导%细胞凋亡
乳腺腫瘤%信號傳導%細胞凋亡
유선종류%신호전도%세포조망
Breast neoplasms%Signal transduction%Apoptosis
维生素E琥珀酸酯( VES)是一种新型肿瘤抑制剂,近年来已得到公认.但是,VES诱导乳腺癌细胞凋亡的机制尚未阐明,目前的研究表明,VES主要通过细胞转化生长因子β (TGF-β)、Fas及c-Jun氨基末端激酶等多种信号途径诱导乳腺癌细胞凋亡,其对肿瘤的抑制作用通过的其他信号转导通路仍在进一步研究当中.
維生素E琥珀痠酯( VES)是一種新型腫瘤抑製劑,近年來已得到公認.但是,VES誘導乳腺癌細胞凋亡的機製尚未闡明,目前的研究錶明,VES主要通過細胞轉化生長因子β (TGF-β)、Fas及c-Jun氨基末耑激酶等多種信號途徑誘導乳腺癌細胞凋亡,其對腫瘤的抑製作用通過的其他信號轉導通路仍在進一步研究噹中.
유생소E호박산지( VES)시일충신형종류억제제,근년래이득도공인.단시,VES유도유선암세포조망적궤제상미천명,목전적연구표명,VES주요통과세포전화생장인자β (TGF-β)、Fas급c-Jun안기말단격매등다충신호도경유도유선암세포조망,기대종류적억제작용통과적기타신호전도통로잉재진일보연구당중.
Vitamin E succinate (VES) has been recently recognized as a neotype tumor suppressor.However, the molecular mechanisms that VES induces apoptosis in breast cancer cells have not been validated. Current studies have indicated that VES induces breast cancer cell apoptosis through TGF-β signaling transduction pathways, Fas signaling transduction pathways, and JNK signaling transduction pathways.Other signaling transduction pathways still need to be investigated further.
