CAJ | 학술논문

目的了解畲族自然人群双侧颈总动脉内中膜厚度(IMT)的变化,判断脉压水平对双侧颈总动脉结构影响的异同性.方法采用"中国动脉僵硬度评价研究"的方法,433名畲族人来自福建省福安市城乡自然人群,年龄15～87(49.03±13.54)岁.根据该人群脉压三分位数水平分为三组:脉压≤48 mm Hg(1 mm Hg=0.133 kPa)、49～59 mm Hg和>59mm Hg.应用超声射频信号血管内中膜分析技术(QIMT)和常规二维超声分别观察记录静息状态下双侧颈总动脉.测量舒张末期IMT,比较双侧颈动脉IMT在各组间的差异和变化趋势,分析其与年龄、体重指数、脉压、总胆固醇、甘油三酯(TG)等危险因素之间的关联.结果 (1)双侧颈动脉IMT随脉压增加而增厚,趋势检验差异有统计学意义(P<0.01).左侧颈总动脉(LCC)IMT在第1分位组与第2分位组间的差异无统计学意义(P>0.05),但均与第3分位组的差异有统计学意义(P<0.05).右侧颈总动脉(RCC)IMT在三组间的差异均有统计学意义(P<0.01).(2)多元线性回归结果表明,进入颈总动脉IMT回归方程的顺序和关联因素.左侧为年龄、脉压、体重、低密度脂蛋白胆固醇(LDL-C)、血糖和TG,其回归方程LCC-IMT=32.61+4.29(年龄)+1.77(脉压)+1.87(体重)+16.52(LDL.C)+11.77(血糖)-9.92(TG),r=0.663,r2=0.44,P<0.001;右侧为年龄、脉压和身高,其回归方程RCC-IMT=5.19(年龄)+1.61(脉压)+2.62(身高)-219.36,r=0.636,r2=0.41,P<0.001.结论畲族自然人群双侧颈动脉IMT随脉压变化存在差异,与年龄、脉压、体重、LDL-C、血糖、TG和身高明显相关.
목적 료해여족자연인군쌍측경총동맥내중막후도(IMT)적변화,판단맥압수평대쌍측경총동맥결구영향적이동성.방법 채용"중국동맥강경도평개연구"적방법,433명여족인래자복건성복안시성향자연인군,년령15～87(49.03±13.54)세.근거해인군맥압삼분위수수평분위삼조:맥압≤48 mm Hg(1 mm Hg=0.133 kPa)、49～59 mm Hg화>59mm Hg.응용초성사빈신호혈관내중막분석기술(QIMT)화상규이유초성분별관찰기록정식상태하쌍측경총동맥.측량서장말기IMT,비교쌍측경동맥IMT재각조간적차이화변화추세,분석기여년령、체중지수、맥압、총담고순、감유삼지(TG)등위험인소지간적관련.결과 (1)쌍측경동맥IMT수맥압증가이증후,추세검험차이유통계학의의(P<0.01).좌측경총동맥(LCC)IMT재제1분위조여제2분위조간적차이무통계학의의(P>0.05),단균여제3분위조적차이유통계학의의(P<0.05).우측경총동맥(RCC)IMT재삼조간적차이균유통계학의의(P<0.01).(2)다원선성회귀결과표명,진입경총동맥IMT회귀방정적순서화관련인소.좌측위년령、맥압、체중、저밀도지단백담고순(LDL-C)、혈당화TG,기회귀방정LCC-IMT=32.61+4.29(년령)+1.77(맥압)+1.87(체중)+16.52(LDL.C)+11.77(혈당)-9.92(TG),r=0.663,r2=0.44,P<0.001;우측위년령、맥압화신고,기회귀방정RCC-IMT=5.19(년령)+1.61(맥압)+2.62(신고)-219.36,r=0.636,r2=0.41,P<0.001.결론 여족자연인군쌍측경동맥IMT수맥압변화존재차이,여년령、맥압、체중、LDL-C、혈당、TG화신고명현상관.
Objective To study the changes of intima-media thickness (IMT) in ambi-common carotid arteries(ambi-CCA)and how they correlated with factors related to quality intima-media thickness(QIMT).Methods According to the Chinese Arterial Stiffness Evaluation (CASE)project,the IMT of (ambi-CCA)was measured by QIMT and 2-D ultrasound respectively in 433 She people aged 15-87(mean 49.03±13.54).Diffrence and tendency were analyzed on age,gender,body mass index(BMI),pulse pressure(PP),total cholesterol(TC),and triglyceride.The whole population was classified into 3 groups by tertiles of pulse pressure.Results (1)Significant positive correlations were found between ambi-CCA IMT and pulse pressure(P<0.01).There was no significant difference between tertilel and tertile 2 of IMT in the left CCA(P>0.05)found,but with significant difference among the tertile groups,respectively(P<0.05).There were significant differences among the three groups of IMT in the right CCA,respectively(P<0.01).(2)The regression factors of IMT in left CCA were age,pulse pressure,weight,LDL-C,blood glucose (BG), TG , and theirregression equation was LCC-IMT=32.61 + 4.29 (age) + 1.77 (PP) + 1.87(weight) + 16.52(LDL-C) + 11.77(BG)-9.92(TG), with r=0.663 and r2=0.44, (P<0.001). The regression factors of IMT in right CCA were age, PP, height and their regression equation was RCC-IMT=5.19(age) + 1.61 (PP) +2.62(height) -219.36,with r=0.636 and r2=0.41 (P<0.001).Conclusion There were differences seen on IMT of CCA in the PP and position and were correlated with age, PP, body weight, LDL-C, BG, TC and body height. The difference of ambi-CCA should be called for attention.