中华病理学杂志
中華病理學雜誌
중화병이학잡지
Chinese Journal of Pathology
2012年
8期
525-529
,共5页
霍真%师晓华%崔全才%罗玉凤%曹金伶%刘鸿瑞
霍真%師曉華%崔全纔%囉玉鳳%曹金伶%劉鴻瑞
곽진%사효화%최전재%라옥봉%조금령%류홍서
支气管扩张症%神经内分泌细胞%免疫组织化学
支氣管擴張癥%神經內分泌細胞%免疫組織化學
지기관확장증%신경내분비세포%면역조직화학
Bronchiectasis%Neuroendocrine cells%Immunohistochemistry
目的 分析肺支气管扩张症伴发肺神经内分泌细胞增生及微小瘤形成病例的临床病理特征.方法 收集22例此类病例,通过光镜下观察及免疫组织化学EnVision法检测分析其临床病理特征及免疫组织化学特点.结果 22例肺支气管扩张症伴发神经内分泌细胞增生及微小瘤形成患者平均年龄53岁,男女比例9∶13,大体检查为典型的支气管扩张症表现,仅1例切面可见灰白色质软结节,直径<5 mm;镜下观察22例均有支气管扩张症表现,在此基础上均可见细小气道上皮细胞下神经内分泌细胞增生并形成微小瘤(直径均<5 mm),10例伴单发微小瘤形成,12例伴多发微小瘤形成,平均直径1.6 mm,淋巴结均未发现特殊改变.术后16例分别随访17~117个月,平均随访58个月,均无类癌发生,1例合并肺癌患者术后猝死,5例失访.免疫组织化学嗜铬粒素A( CgA,18/18)、突触素(16/16)、AE1/AE3(16/16)、TTF-1(14/15)、CD56( 14/14)均阳性,12例Ki-67阳性指数均<2%.结论 免疫组织化学CgA、突触素、CD56、TTF-1、AE1/AE3有助于诊断.早期发现、手术切除和密切随访有助于阻止疾病进展.
目的 分析肺支氣管擴張癥伴髮肺神經內分泌細胞增生及微小瘤形成病例的臨床病理特徵.方法 收集22例此類病例,通過光鏡下觀察及免疫組織化學EnVision法檢測分析其臨床病理特徵及免疫組織化學特點.結果 22例肺支氣管擴張癥伴髮神經內分泌細胞增生及微小瘤形成患者平均年齡53歲,男女比例9∶13,大體檢查為典型的支氣管擴張癥錶現,僅1例切麵可見灰白色質軟結節,直徑<5 mm;鏡下觀察22例均有支氣管擴張癥錶現,在此基礎上均可見細小氣道上皮細胞下神經內分泌細胞增生併形成微小瘤(直徑均<5 mm),10例伴單髮微小瘤形成,12例伴多髮微小瘤形成,平均直徑1.6 mm,淋巴結均未髮現特殊改變.術後16例分彆隨訪17~117箇月,平均隨訪58箇月,均無類癌髮生,1例閤併肺癌患者術後猝死,5例失訪.免疫組織化學嗜鉻粒素A( CgA,18/18)、突觸素(16/16)、AE1/AE3(16/16)、TTF-1(14/15)、CD56( 14/14)均暘性,12例Ki-67暘性指數均<2%.結論 免疫組織化學CgA、突觸素、CD56、TTF-1、AE1/AE3有助于診斷.早期髮現、手術切除和密切隨訪有助于阻止疾病進展.
목적 분석폐지기관확장증반발폐신경내분비세포증생급미소류형성병례적림상병리특정.방법 수집22례차류병례,통과광경하관찰급면역조직화학EnVision법검측분석기림상병리특정급면역조직화학특점.결과 22례폐지기관확장증반발신경내분비세포증생급미소류형성환자평균년령53세,남녀비례9∶13,대체검사위전형적지기관확장증표현,부1례절면가견회백색질연결절,직경<5 mm;경하관찰22례균유지기관확장증표현,재차기출상균가견세소기도상피세포하신경내분비세포증생병형성미소류(직경균<5 mm),10례반단발미소류형성,12례반다발미소류형성,평균직경1.6 mm,림파결균미발현특수개변.술후16례분별수방17~117개월,평균수방58개월,균무유암발생,1례합병폐암환자술후졸사,5례실방.면역조직화학기락립소A( CgA,18/18)、돌촉소(16/16)、AE1/AE3(16/16)、TTF-1(14/15)、CD56( 14/14)균양성,12례Ki-67양성지수균<2%.결론 면역조직화학CgA、돌촉소、CD56、TTF-1、AE1/AE3유조우진단.조기발현、수술절제화밀절수방유조우조지질병진전.
Objective To study the clinical and pathological features of pulmonary neuroendocrine cell hyperplasia and tumodets with bronchiectasis. Methods Both the clinicopathologic changes and immunohistochemical findings were examined with microscopy and EnVision method in 22 cases of pulmonary neuroendocrine cell hyperplasia and tumorlets.Results The average age of the 22 patients was 53 years,with a male to female ratio of 9∶13.On macroscopic examination the lungs showed bronchiectasis; one case was accompanied by gray-white,soft nodules (diameter < 5 mm).Microscopy of the HE sections showed the basic pathologic change was bronchiectasis,accompanied by neuroendocrine cell hyperplasia and tumorlet formation in the pulmonary parenchyma surrounding the bronchioles,presenting as single nodule (10 patients),or multifocal nodules (12 patients),with average size of 1.6 mm in diameter.No tumor cells were identified in the lymph nodes.Sixteen of 22 patients were disease-free after an average follow-up period of 58 months (17-117 months); one patient died suddenly after surgery; and five were loss of follow up.Immunohistologically,the tumor cells were positive for CgA (18/18),Syn (16/16),AE1/AE3 (16/16),TTF-1 (14/15), and CD56 (14/14), and Ki-67 index was < 2% in 12 cases. Conclusions Immunohistological staining for CgA,Syn,CD56,TTF-1 and AE1/AE3 can confirm the diagnosis.Early detection,pulmonary resection and follow-up help prevent the progression of these diseases.