CAJ | 학술논문

目的探讨巨噬细胞移动抑制因子(MIF)在卵巢子宫内膜异位症(OEms)组织中表达的意义.方法应用ElivisionTm plus免疫组化方法检测30例OEms异位、在位内膜和非子宫内膜异位症(Ems)子宫内膜组织(对照组)中的MIF,并应用计算机图像分析系统对结果进行体视学指标平均吸光度的检测.结果 OEms组异位内膜、在位内膜及对照组中MIF的吸光度分别为(0.180±0.013)、(0.158 ±0.022)及(0.143±0.029),3组间比较,差异有统计学意义(F =47.676,P＜0.001).MIF蛋白在OEms组在位内膜增生期和分泌期的表达均高于对照组同期水平(0.157±0.018与0.146±0.029,t=2.656,P=0.009；0.160 ±0.028与0.137±0.030,t=3.059,P=0.003).结论 MIF可能在Ems的发生、发展过程中起重要作用.
목적 탐토거서세포이동억제인자(MIF)재란소자궁내막이위증(OEms)조직중표체적의의.방법 응용ElivisionTm plus면역조화방법검측30례OEms이위、재위내막화비자궁내막이위증(Ems)자궁내막조직(대조조)중적MIF,병응용계산궤도상분석계통대결과진행체시학지표평균흡광도적검측.결과 OEms조이위내막、재위내막급대조조중MIF적흡광도분별위(0.180±0.013)、(0.158 ±0.022)급(0.143±0.029),3조간비교,차이유통계학의의(F =47.676,P＜0.001).MIF단백재OEms조재위내막증생기화분비기적표체균고우대조조동기수평(0.157±0.018여0.146±0.029,t=2.656,P=0.009；0.160 ±0.028여0.137±0.030,t=3.059,P=0.003).결론 MIF가능재Ems적발생、발전과정중기중요작용.
Objective To investigate the significance of macrophage migration inhibitory factor(MIF) in ovarian endometriosis (OEms).Methods MIF of ectopic endometriumeutopic endometrium in OEms and endometrium in non-endometriosis (30 cases in every group ) was detected by Elivision TM plus immunohistochemical.Quantitative images analytical system was performed with computer to analyze the mean absorbance(A) of MIF.Results The A of MIF in ectopic and eutopic endometrium of OEms and the normal control was respectively ( 0.180 ± 0.013 ),( 0.158 ± 0.022 ) and ( 0.143 ± 0.029 ),there was statistical significance between groups ( F =47.676,P ＜ 0.001 ).The expression of MIF in proliferative phase of eutopic endometrium of OEms was(0.157 ±0.018),extremely stronger than that in the same phase of the normal control (0.146 ± 0.029 ) ( t =2.656,P =0.009 ) ; and MIF in secretory phase of eutopic endometrium of OEms was (0.160±0.028),obviously higher than that in the same phase of the normal control(0.137 ±0.030) (t =3.059,P =0.003).Conclusion The MIF may play a significant role in the pathogenesis and development of ovarian endometriosis.