国际流行病学传染病学杂志
國際流行病學傳染病學雜誌
국제류행병학전염병학잡지
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY AND INFECTIOUS DISEASE
2011年
2期
90-92
,共3页
肝炎,乙型,慢性%配偶%HBV感染
肝炎,乙型,慢性%配偶%HBV感染
간염,을형,만성%배우%HBV감염
Hepatitis B,chronic%Spouses%HBV infection
目的 通过对慢性HBV感染者及其配偶HBV感染状况的调查和分析,评价婚后生活接触与慢性HBV感染之间的关系.方法 选择婚前即为慢性HBV感染者、且婚后血清HBV DNA阳性的慢性HBV感染者,调查其配偶人群的家族史、献血史、输血史、吸毒史、健康体检史、婚检史、婚外性接触史及乙型肝炎疫苗接种史等,排除婚前已感染HBV或接种乙型肝炎疫苗的配偶.对68对入选夫妻双方进行HBV血清免疫学标志物和HBV DNA定量进行检测.入选的夫妻,结婚时间为平均12.5年(0.5～35年).结果 配偶人群中至少1项HBV血清标志物阳性者54例(79.4%),其中HBV DNA阳性者4例,研究对象的HBV感染后慢性化率为7.4%,与人群中成年人感染HBV后的慢性化率(5%～10%)相似;抗-HBs 阳性者48例(88.9%),与健康人群接种乙型肝炎疫苗后抗-HBs的阳性率(85%～90%)相似.男性配偶中,至少1项HBV血清标志物阳性者22例(22/24),占91.7%;女性配偶32例(32/44),占72.7%,二者差异无统计学意义(χ2＝2.681,P>0.05).结论 慢性乙型肝炎患者的配偶是否感染HBV与其结婚时间长短、性别及患者方的HBV DNA定量水平高低均无明显相关性.健康者与慢性HBV感染者婚配后HBV感染的机会增加,但转为慢性HBV感染的机会未见明显增加.
目的 通過對慢性HBV感染者及其配偶HBV感染狀況的調查和分析,評價婚後生活接觸與慢性HBV感染之間的關繫.方法 選擇婚前即為慢性HBV感染者、且婚後血清HBV DNA暘性的慢性HBV感染者,調查其配偶人群的傢族史、獻血史、輸血史、吸毒史、健康體檢史、婚檢史、婚外性接觸史及乙型肝炎疫苗接種史等,排除婚前已感染HBV或接種乙型肝炎疫苗的配偶.對68對入選伕妻雙方進行HBV血清免疫學標誌物和HBV DNA定量進行檢測.入選的伕妻,結婚時間為平均12.5年(0.5～35年).結果 配偶人群中至少1項HBV血清標誌物暘性者54例(79.4%),其中HBV DNA暘性者4例,研究對象的HBV感染後慢性化率為7.4%,與人群中成年人感染HBV後的慢性化率(5%～10%)相似;抗-HBs 暘性者48例(88.9%),與健康人群接種乙型肝炎疫苗後抗-HBs的暘性率(85%～90%)相似.男性配偶中,至少1項HBV血清標誌物暘性者22例(22/24),佔91.7%;女性配偶32例(32/44),佔72.7%,二者差異無統計學意義(χ2＝2.681,P>0.05).結論 慢性乙型肝炎患者的配偶是否感染HBV與其結婚時間長短、性彆及患者方的HBV DNA定量水平高低均無明顯相關性.健康者與慢性HBV感染者婚配後HBV感染的機會增加,但轉為慢性HBV感染的機會未見明顯增加.
목적 통과대만성HBV감염자급기배우HBV감염상황적조사화분석,평개혼후생활접촉여만성HBV감염지간적관계.방법 선택혼전즉위만성HBV감염자、차혼후혈청HBV DNA양성적만성HBV감염자,조사기배우인군적가족사、헌혈사、수혈사、흡독사、건강체검사、혼검사、혼외성접촉사급을형간염역묘접충사등,배제혼전이감염HBV혹접충을형간염역묘적배우.대68대입선부처쌍방진행HBV혈청면역학표지물화HBV DNA정량진행검측.입선적부처,결혼시간위평균12.5년(0.5～35년).결과 배우인군중지소1항HBV혈청표지물양성자54례(79.4%),기중HBV DNA양성자4례,연구대상적HBV감염후만성화솔위7.4%,여인군중성년인감염HBV후적만성화솔(5%～10%)상사;항-HBs 양성자48례(88.9%),여건강인군접충을형간염역묘후항-HBs적양성솔(85%～90%)상사.남성배우중,지소1항HBV혈청표지물양성자22례(22/24),점91.7%;녀성배우32례(32/44),점72.7%,이자차이무통계학의의(χ2＝2.681,P>0.05).결론 만성을형간염환자적배우시부감염HBV여기결혼시간장단、성별급환자방적HBV DNA정량수평고저균무명현상관성.건강자여만성HBV감염자혼배후HBV감염적궤회증가,단전위만성HBV감염적궤회미견명현증가.
Objective To evaluate the influence of daily contact on HBV infection between hepatitis B virus carriers and their spouses by investigating the infection situation after marriage. Methods Premarital HBV carriers of serum HBV DNA positive were enrolled, family history, the histoty of blood donation, blood transfusion, drug abuse,physical examination, premarriage medical check, extramarital sex and hepatitis B vaccine were investigated in their spouses. Couples who were infected before marriage or vaccined with HBV vaccine were excluded. 68 couples were enrolled with an average marriage time of 12.5 years (0.5-35 years), their HBV serum markers and quantitative were performed. Results In the 68 couples, 54(79.4%) spouses were serum HBV marker positive, of the 54 spouses, 4 were HBV DNA positive. The chronic rate of HBV infection in the spouses was 7.4%, and was similar to the rate in general population(5%-10%). 48(88.9%) spouses were anti-HBs positive, the positive rate was similar to the rate in vaccinated population (85%-90%). Male spouses with at least one HBV marker positive were 22 cases (22/24), occupied 91.7% , female spouses were 32(32/44), occupied 72.7%, there was no difference between the male and female spouses(χ2 = 2.681, P > 0.05). Conclusions Whether HBV carriers' spouse infected with HBV is not correlated with marriage time, gender and HBV DNA level of carriers. HBV infection rate of the healthy people increases after marriage with HBV carriers, but the rate of chronic HBV infection is not increased obviouly.
