CAJ | 학술논문

目的探讨缺氧缺血性脑病(HIE)新生儿血清皮质醇(COR)和血糖(GLU)水平的变化及其临床意义.方法对81例HIE新生儿和30例对照组进行GLU和COR检测并分析.结果 HIE患儿除轻度组外,血清GLU水平均显著高于对照组(P＜0.05)；HIE患儿COR水平均明显高于对照组(P＜ 0.01); HIE程度越重,血清GLU和COR水平升高越明显；治疗后,HIE患儿血清COR含量呈下降趋势.结论临床治疗HIE过程中要严密观察GLU和COR的变化,严格控制葡萄糖输注的量及速度,应用糖皮质激素时严格掌握其适应证及剂量,以防止肾上腺皮质萎缩、高血糖的发生,以减少后遗症和HIE患儿死亡率.
목적 탐토결양결혈성뇌병(HIE)신생인혈청피질순(COR)화혈당(GLU)수평적변화급기림상의의.방법 대81례HIE신생인화30례대조조진행GLU화COR검측병분석.결과 HIE환인제경도조외,혈청GLU수평균현저고우대조조(P＜0.05)；HIE환인COR수평균명현고우대조조(P＜ 0.01); HIE정도월중,혈청GLU화COR수평승고월명현；치료후,HIE환인혈청COR함량정하강추세.결론 림상치료HIE과정중요엄밀관찰GLU화COR적변화,엄격공제포도당수주적량급속도,응용당피질격소시엄격장악기괄응증급제량,이방지신상선피질위축、고혈당적발생,이감소후유증화HIE환인사망솔.
Objective To investigate the changes and clinical significance of glucose (GLU) and serum cortical (COR) in neonates with hypoxic-ischemic encephalopathy (HIE).Methods A total of 81 neonates with HIE and 30 healthy neonates were enrolled in this study for measurement of serum concentrations of GLU and COR.Results The level of serum GLU in HIE groups except slight was higher than that of control group (P ＜ 0.05); the concentration of serum COR of neonate with HIE was significantly higher than that of control group (P＜ 0.01).The more severe degree of HIE was,the higher level of GLU and COR increased; after treatment,the concentration of serum COR of 81 neonates with hyperglycemia decreased.Conclusions Clinical treatment during the process of HIE need strict observation to the COR and GLU changes,strictly control the amount of glucose infusion and speed.Use of corticosteroids strictly grasps its indication and dose,preventing adrenal cortical atrophy and high blood sugar from happening,in order to reduce sequels and HIE children mortality.