CAJ | 학술논문

目的评价肾小球滤过率(GFR)评估方程在老年慢性肾脏病(CKD)患者的适用性.方法选择老年CKD患者103例,采用Cockcroft-Gauh(CG)方程、MDRD1方程、简化MDRD方程、Jelliffe1973(JE73)方程、Mawer(MA)方程、Hull(HU)方程、Jellife1971(JE71)方程、血肌酐倒数公式,Gate(GA)方程、Bjornsson(BJ)方程,分别预测GFR值,与""Tc DTPA肾动态显像检测的GFR(sGFR)进行比较. 结果 Bland-Ahman分析显示,CG方程、BJ方程和HU方程估计的GFR与sGFR的一致性较好,但所有各方程估计的GFR与sGFR的一致性限度均超过事先规定的专业界值.线性回归结果显示,JE方程和CG方程估测的GFR与X轴的斜率较其他方程更接近0,MDRD1方程较其他方程有较小的偏差;在所有方程中,BJ方程、JE方程和CG方程GFR符合率较高.在CKD的不同分期中,BJ方程、CG方程和JE方程具有较小的偏差和更优的准确性. 结论当血肌酐的测定方法为酶法时,如果直接应用目前临床常用的GFR评估方程预测老年CKD患者的GFR,可能会产生明显的偏差.J方程和HU方程估计的GFR与sGFR的一致性较好,但所有各方程估计的GFR与sGFR的一致性限度均超过事先规定的专业界值.线性回归结果显示,JE方程和CG方程估测的GFR与X轴的斜率较其他方程更接近0,MDRD1方程较其他方程有较小的偏差;在所有方程中,BJ方程、JE方程和CG方程GFR符合率较高.在CKD的不同分期中,BJ方程、CG方程和JE方程具有较小的偏差和更优的准确性. 结论当血肌酐的测定方法为酶法时,如果直接应用目前临床常用的GFR评估方程预测老年CKD患者的GFR,可能会产
목적 평개신소구려과솔(GFR)평고방정재노년만성신장병(CKD)환자적괄용성.방법 선택노년CKD환자103례,채용Cockcroft-Gauh(CG)방정、MDRD1방정、간화MDRD방정、Jelliffe1973(JE73)방정、Mawer(MA)방정、Hull(HU)방정、Jellife1971(JE71)방정、혈기항도수공식,Gate(GA)방정、Bjornsson(BJ)방정,분별예측GFR치,여""Tc DTPA신동태현상검측적GFR(sGFR)진행비교. 결과 Bland-Ahman분석현시,CG방정、BJ방정화HU방정고계적GFR여sGFR적일치성교호,단소유각방정고계적GFR여sGFR적일치성한도균초과사선규정적전업계치.선성회귀결과 현시,JE방정화CG방정고측적GFR여X축적사솔교기타방정경접근0,MDRD1방정교기타방정유교소적편차;재소유방정중,BJ방정、JE방정화CG방정GFR부합솔교고.재CKD적불동분기중,BJ방정、CG방정화JE방정구유교소적편차화경우적준학성. 결론 당혈기항적측정방법 위매법시,여과직접응용목전림상상용적GFR평고방정예측노년CKD환자적GFR,가능회산생명현적편차.J방정화HU방정고계적GFR여sGFR적일치성교호,단소유각방정고계적GFR여sGFR적일치성한도균초과사선규정적전업계치.선성회귀결과 현시,JE방정화CG방정고측적GFR여X축적사솔교기타방정경접근0,MDRD1방정교기타방정유교소적편차;재소유방정중,BJ방정、JE방정화CG방정GFR부합솔교고.재CKD적불동분기중,BJ방정、CG방정화JE방정구유교소적편차화경우적준학성. 결론 당혈기항적측정방법 위매법시,여과직접응용목전림상상용적GFR평고방정예측노년CKD환자적GFR,가능회산
Objective To evaluate the applicability of glomerular filtration rate estimation equations in elderly Chinese patients with chronic kidney disease(CKD). Methods A total of 103 elderly CKD patients were investigated. Glomerular filtration rate (GFR) was estimated by Coekcroft -Gault equation, MDRD1 equation, abbreviated MDRD equation, Jellife 1973 equation, Mawer equation, Hull equation, Jellife 1971 equation, plasma creatinine reciprocal equation, Gate equation and Bjornsson equation. The accuracy of estimated GFRs was compared with that of GFR estimated by 99mTe-DTPA-GFR (sGFR)in elderly CKD patients. Results Bland-Altman analysis demonstrated that GFRs evaluated by Cockcroft -Gault equation, Bjornsson equation and Hull equation were more consistent with sGFR than the other equations. But all the equations were not well consistent with sGFR. Linear regression showed that the slopes of Jellife 1973 equation and Cockcroft-Gault equation were closer to the identical line. Bias of MDRD1 equation was smaller. Accuracy of Bjornsson equation, Jellife 1973 equation and Cockcroft-Gault equation were higher than the other equations. When comparing the bias as well as accuracy of estimated GFRs with sGFR in different stages of CKD, GFR estimated by Bjornsson equation, Coekcroft-Gault equation and Jellife1973 equation showed better Results . Conclusions When plasma creatinine is checked by enzymatic method, GFR estimating equations may show great bias in elderly Chinese CKD patients.