中国临床实用医学
中國臨床實用醫學
중국림상실용의학
CHINA CLINICAL PRACTICAL MEDICINE
2010年
7期
96-97
,共2页
艾迪%联合化疗%非小细胞肺癌
艾迪%聯閤化療%非小細胞肺癌
애적%연합화료%비소세포폐암
Aidi injection%Non-small cell lung cancer%Clinical study
目的 为提高疗效,改善患者生活质量,降低毒副反应,本研究对艾迪联合化疗和单纯化疗治疗中晚期非小细胞肺癌的疗效、毒副反应及对生存质量的影响进行了比较.方法 将86例患者随机分成两组.单纯化疗组(对照组)43例,采用HAP方案:HCPT 10 mg,静脉滴注,d1～5,EPI 50～70 mg,静脉滴注,d1,DDP40 mg,静脉滴注,d1～3,3周为一周期.艾迪联合化疗组(艾迪组)43例,化疗方案同对照组,同时给予艾迪注射液100 ml加入5%葡萄糖注射液或氯化钠注射液400 ml中静脉滴注,1次/d,每个月连用10 d为1个周期.两周期治疗结束后对其近期疗效、毒副反应及生存质量进行评价.结果 艾迪组有效率为52%,对照组为32%,两组比较差异有统计学意义(χ2=4.67,P＜0.05).两组治疗后的生存质量差异有统计学意义(t=6.6,P＜0.05).艾迪组的不良反应发生率低于对照组,且发生的程度较轻.结论 艾迪联合化疗能提高有效率,降低不良反应,改善患者的生存质量.
目的 為提高療效,改善患者生活質量,降低毒副反應,本研究對艾迪聯閤化療和單純化療治療中晚期非小細胞肺癌的療效、毒副反應及對生存質量的影響進行瞭比較.方法 將86例患者隨機分成兩組.單純化療組(對照組)43例,採用HAP方案:HCPT 10 mg,靜脈滴註,d1～5,EPI 50～70 mg,靜脈滴註,d1,DDP40 mg,靜脈滴註,d1～3,3週為一週期.艾迪聯閤化療組(艾迪組)43例,化療方案同對照組,同時給予艾迪註射液100 ml加入5%葡萄糖註射液或氯化鈉註射液400 ml中靜脈滴註,1次/d,每箇月連用10 d為1箇週期.兩週期治療結束後對其近期療效、毒副反應及生存質量進行評價.結果 艾迪組有效率為52%,對照組為32%,兩組比較差異有統計學意義(χ2=4.67,P＜0.05).兩組治療後的生存質量差異有統計學意義(t=6.6,P＜0.05).艾迪組的不良反應髮生率低于對照組,且髮生的程度較輕.結論 艾迪聯閤化療能提高有效率,降低不良反應,改善患者的生存質量.
목적 위제고료효,개선환자생활질량,강저독부반응,본연구대애적연합화료화단순화료치료중만기비소세포폐암적료효、독부반응급대생존질량적영향진행료비교.방법 장86례환자수궤분성량조.단순화료조(대조조)43례,채용HAP방안:HCPT 10 mg,정맥적주,d1～5,EPI 50～70 mg,정맥적주,d1,DDP40 mg,정맥적주,d1～3,3주위일주기.애적연합화료조(애적조)43례,화료방안동대조조,동시급여애적주사액100 ml가입5%포도당주사액혹록화납주사액400 ml중정맥적주,1차/d,매개월련용10 d위1개주기.량주기치료결속후대기근기료효、독부반응급생존질량진행평개.결과 애적조유효솔위52%,대조조위32%,량조비교차이유통계학의의(χ2=4.67,P＜0.05).량조치료후적생존질량차이유통계학의의(t=6.6,P＜0.05).애적조적불량반응발생솔저우대조조,차발생적정도교경.결론 애적연합화료능제고유효솔,강저불량반응,개선환자적생존질량.
Objective To observe the therapeutic efficacy of Aidi injection in treament of advanced Non-small cell lung cancer.Methods 86 patients with Non-small cell lung cancer were divided randomly into two groups.That is group of chemotherapy and group of chemotherapy combioned with Aidi injection.The therapeutic efficacy of the two groups were evaluated after two cycle treatment.Results The complete and partial remission rate( CR + PR) of group chemotherapy was lower than that of group chemotherapy combined with Aidi injection(P ＜ 0.05 ) ;the stable rate of group chemotherapy combined with Aidi injection had a better effect than that of group chemotherapy( P ＜ 0.05 ) ;the statle rate of group chemotherapy combined with Aidi injection had a better effect of raising the quality of life and weight than that of group chemotherapy( P ＜ 0.05 );the rate of bone marrow depression in group chemotherapy combioned with Aidi injection was lower statistically than that in group chemotherapy(P ＜ 0.05).Conclusion Aidi injection could alleviate the symptoms,improve the quality of life in the advanced Non-small cell lung cancer patients,reduce the toxicity of chemotherapy.
