国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2008年
13期
777-779
,共3页
呼吸机相关性肺炎%病原学%抗生素%耐药性
呼吸機相關性肺炎%病原學%抗生素%耐藥性
호흡궤상관성폐염%병원학%항생소%내약성
Ventilator-associated pneumonia%Etiology%Antibiotics%Drug-resistance
目的 监测重症监护病房(ICU)中呼吸机相关性肺炎(ventilator-associated pneumonia,VAP)患者下呼吸道病原菌的分布及其耐药性,为临床治疗VAP提供经验性选药依据.方法 经人工气道采集患者下呼吸道分泌物标本,对连续2次培养为同一优势致病菌的菌株纳入本研究中,采用纸片法测定该菌的体外药物敏感性.结果 51例检出89株致病菌,其中革兰阴性细菌占78.7%(70/89),革兰阳性细菌占6.7%(6/89),真菌占14.6%(13/89),药敏结果显示这类菌株耐药现象严重.结论 ICU中VAP患者的感染致病菌以革兰阴性菌为主,呈多重耐药,提倡严密动态监测VAP病原菌,应重视并强调对抗生素药物的合理应用.
目的 鑑測重癥鑑護病房(ICU)中呼吸機相關性肺炎(ventilator-associated pneumonia,VAP)患者下呼吸道病原菌的分佈及其耐藥性,為臨床治療VAP提供經驗性選藥依據.方法 經人工氣道採集患者下呼吸道分泌物標本,對連續2次培養為同一優勢緻病菌的菌株納入本研究中,採用紙片法測定該菌的體外藥物敏感性.結果 51例檢齣89株緻病菌,其中革蘭陰性細菌佔78.7%(70/89),革蘭暘性細菌佔6.7%(6/89),真菌佔14.6%(13/89),藥敏結果顯示這類菌株耐藥現象嚴重.結論 ICU中VAP患者的感染緻病菌以革蘭陰性菌為主,呈多重耐藥,提倡嚴密動態鑑測VAP病原菌,應重視併彊調對抗生素藥物的閤理應用.
목적 감측중증감호병방(ICU)중호흡궤상관성폐염(ventilator-associated pneumonia,VAP)환자하호흡도병원균적분포급기내약성,위림상치료VAP제공경험성선약의거.방법 경인공기도채집환자하호흡도분비물표본,대련속2차배양위동일우세치병균적균주납입본연구중,채용지편법측정해균적체외약물민감성.결과 51례검출89주치병균,기중혁란음성세균점78.7%(70/89),혁란양성세균점6.7%(6/89),진균점14.6%(13/89),약민결과현시저류균주내약현상엄중.결론 ICU중VAP환자적감염치병균이혁란음성균위주,정다중내약,제창엄밀동태감측VAP병원균,응중시병강조대항생소약물적합리응용.
Objective The pathogens and antibiotic resistance in patients with ventilator-associated pneumonia(VAP)were explored to provide the corresponding clinical treatment strategies.Methods Fifty-one VAP patients were retrospectively investigated.Bacteria from the secretion of lower respiratory tract after endotracheal intubation were cultivated.Drug sensitivity of Stenotrophomonas maltophilia was studied by kirby-Bauer method.Results In 51 patients,89 strains of pathogens were gram-negative bacteria[78.7%(70/89)],gram-positive cocci[6.7%(6/89)]and fungi[14.6%(13/89)].Conclusions Gram-negative bacteria are the most common pathogens of VAP,which present to multi-drug resistant pattern.Exact and dynamical monitoring of VAP pathogens and antibiotic resistance are advocated.Preventive treatment and reasonable application of antibiotics should be emphasized.
