CAJ | 학술논문

目的运用脑功能磁共振成像(fMRI)技术探讨人脑纹状体是否参与语义的联想学习记忆的认知过程.方法 14名右利手健康志愿者进行一项词语联想学习记忆任务的同时行fMRI扫描.试验采用组块设计并用SPM99软件行数据分析和脑功能区定位.收集纹状体损伤患者和年龄等相匹配健康者各14例分别进行词语联想学习记忆量表测试.采用单样本t检验,阈值设为P＜0.05.结果左枕叶在任务的编码时被显著激活(激活强度t值=13.87),左顶叶在记忆提取阶段被显著激活(激活强度t值=8.73);纹状体在记忆的两阶段均被明显激活(激活强度t值=7.02/7.47);纹状体损伤患者和年龄等匹配健康者的词语联想学习记忆量表测试的成绩分别是(11.53±1.39)分和(19.18±2.89)分,纹状体损伤者成绩明显低于健康者(P＜0.01).结论人脑处理语义的联想学习记忆信息是由皮质和纹状体等皮质下结构共同协作完成的;纹状体损伤患者会出现词语联想学习记忆认知功能障碍.
목적 운용뇌공능자공진성상(fMRI)기술탐토인뇌문상체시부삼여어의적련상학습기억적인지과정.방법 14명우리수건강지원자진행일항사어련상학습기억임무적동시행fMRI소묘.시험채용조괴설계병용SPM99연건행수거분석화뇌공능구정위.수집문상체손상환자화년령등상필배건강자각14례분별진행사어련상학습기억량표측시.채용단양본t검험,역치설위P＜0.05.결과 좌침협재임무적편마시피현저격활(격활강도t치=13.87),좌정협재기억제취계단피현저격활(격활강도t치=8.73);문상체재기억적량계단균피명현격활(격활강도t치=7.02/7.47);문상체손상환자화년령등필배건강자적사어련상학습기억량표측시적성적분별시(11.53±1.39)분화(19.18±2.89)분,문상체손상자성적명현저우건강자(P＜0.01).결론 인뇌처리어의적련상학습기억신식시유피질화문상체등피질하결구공동협작완성적;문상체손상환자회출현사어련상학습기억인지공능장애.
Objective To examine whether the striatum are involved in associative learning and memory cognitive function of human brain by functional magnetic resonance imaging (fMRI) technique and clinical observation.Methods 14 right-handed normal volunteers participated in a test of paired-word associative learning and memory ,while the fMRI data were recorded.Control tasks were performed for the block-design.SPM 99 was used to analyze the data and to obtain the activated brain regions.14 patients with striatum damages and 14 matched normal volunteers participated in a test of paired-word associative learning and memory.Results When the threshold was set as P＜0.005 ,using a one-sample t -test ,the left occipital lobe (t=13.87)were activated remarkably during the encoding process of the paired-word associative learning and memory task.However,during the retrieval process,the prominently activated brain regions were the left parietal lobe (t=8.73).The striatum (t=7.02/7.47) were also obviously activated during these two stages.The scores of the paired-word associative learning and memory test on the patients with striatum damages and the healthy volunteers were respectively 11.53±1.39 and 19.18±2.89 ,the difference was significant (P ＜ 0.001).Conclusion The results of this study reveal that the subcortical structures such as the striatum as well as the cerebral cortex are involved in the associative learning and memory in human brain ,and the damages of striatum would show the disorder of associative learning and memory cognitive function.