CAJ | 학술논문

对硫代呋喃甲酸进行精制,用乙酸乙酯作溶剂,与7-ACA反应得到头孢呋酸[收率95.6%,含量≥98.0%（HPLC归一化法）],在三乙胺作用下直接与AE-活性酯缩合得到头孢噻呋[收率74.2%,含量≥95.0%（HPLC外标法）],产品可直接制备冻干粉。
대류대부남갑산진행정제,용을산을지작용제,여7-ACA반응득도두포부산[수솔95.6%,함량≥98.0%（HPLC귀일화법）],재삼을알작용하직접여AE-활성지축합득도두포새부[수솔74.2%,함량≥95.0%（HPLC외표법）],산품가직접제비동간분。
Purified 3-thiofuroyi-formic acid reacts with 7-ACA to get 3-thiofuroyi-7-aminocephalosporanic acid using ethyl acetate as solvent（yield：95.6%）,highly pure product（≥98.0%,HPLC）.Under the action of triethylamine,3-thiofuroyi-7-aminocephalosporanic acid reacts with AE-thiolester to get ceftiofur（yield：74.2%）,highly pure product（≥95.0%,HPLC）,which can be prepared for freeze-dried powder directly.