CAJ | 학술논문

苦参碱作为一种广泛存在于豆科植物的天然产物,具有多方面的药理活性,对人体心血管系统具有抗心律失常、抗慢性心功能不全、抗心肌细胞纤维化,保护心肌缺血等作用.近10年来国内外研究者通过大量实验分别探讨了苦参碱对于心血管系统的药理活性及其机制,本文对苦参碱的心血管系统药理作用及其机制进行了综述性研究,研究表明苦参碱通过作用于细胞的离子通道,活性蛋白以及信号转导通路等来发挥作用.
고삼감작위일충엄범존재우두과식물적천연산물,구유다방면적약리활성,대인체심혈관계통구유항심률실상、항만성심공능불전、항심기세포섬유화,보호심기결혈등작용.근10년래국내외연구자통과대량실험분별탐토료고삼감대우심혈관계통적약리활성급기궤제,본문대고삼감적심혈관계통약리작용급기궤제진행료종술성연구,연구표명고삼감통과작용우세포적리자통도,활성단백이급신호전도통로등래발휘작용.
The matrine-type of alkaloids, a kind of natural product, which mostly exist in leguminous plants are of various pharmacological activities. Matrine attributes to treating those diseases in cardiovascular system. Previous studies has indicated that the functions of matrine on cardiovascular system contain anti-arrhythmic,anti-chronic cardiac insufficiency, anti-fiberization etc, and explained the mechanisms of those activities. This article intends to summarize the research progress of matrines effects on cardiovascular system and its mechanisms in recent 10 years. The research in this paper indicates that matrine exerts its pharmacological activities by its effects on ion channel,active protein and signal transduction pathway.