内蒙古民族大学学报：自然科学版
內矇古民族大學學報：自然科學版
내몽고민족대학학보：자연과학판
Journal of Inner Mongolia University for the Nationalities(Natural Sciences)
2011年
4期
452-456
,共5页
长白山红景天%抗疲劳%1,6一二磷酸果糖%小鼠
長白山紅景天%抗疲勞%1,6一二燐痠果糖%小鼠
장백산홍경천%항피로%1,6일이린산과당%소서
R.angusta Nakai%Anti-fatigue%Fructose-1%6-diphospphate（FDP）%Mice
目的：实验研究长白山红景天配伍1,6-二磷酸果糖（FDP）抗疲劳作用,探讨其抗疲劳作用机制,寻找最佳配伍剂量,为研发长白山红景天配伍FDP抗疲劳口服制剂提供动物实验依据.方法：试验采用不同剂量长白山红景天和FDP及其配伍剂量灌胃小鼠,通过对力竭游泳时间、血乳酸含量、肝糖原含量、SOD活力、乳酸脱氢酶活力等的测定,观察红景天及其配伍FDP抗疲劳效果,并探讨其可能的抗疲劳机制.结果：长白山红景天10g/kg、FDP 200mg/kg剂量组效果显著.析因分析得出在配伍剂量下长白山红景天与FDP存在交互关系,配伍剂量组强于单剂量组,更强于对照组.结论：长白山红景天与FDP配伍可显著增强乳酸脱氢酶活力,减少无氧运动后乳酸的堆积,提高机体对抗疲劳的能力;显著提高运动后小鼠肝糖原水平,增加有氧运动糖份供给;配伍还能够提高超氧化物歧化酶活力,加快清除自由基,增强保护组织细胞生物膜作用,延缓疲劳发生,口服长白山红景天配伍FDP是安全有效的抗疲劳途径.
目的：實驗研究長白山紅景天配伍1,6-二燐痠果糖（FDP）抗疲勞作用,探討其抗疲勞作用機製,尋找最佳配伍劑量,為研髮長白山紅景天配伍FDP抗疲勞口服製劑提供動物實驗依據.方法：試驗採用不同劑量長白山紅景天和FDP及其配伍劑量灌胃小鼠,通過對力竭遊泳時間、血乳痠含量、肝糖原含量、SOD活力、乳痠脫氫酶活力等的測定,觀察紅景天及其配伍FDP抗疲勞效果,併探討其可能的抗疲勞機製.結果：長白山紅景天10g/kg、FDP 200mg/kg劑量組效果顯著.析因分析得齣在配伍劑量下長白山紅景天與FDP存在交互關繫,配伍劑量組彊于單劑量組,更彊于對照組.結論：長白山紅景天與FDP配伍可顯著增彊乳痠脫氫酶活力,減少無氧運動後乳痠的堆積,提高機體對抗疲勞的能力;顯著提高運動後小鼠肝糖原水平,增加有氧運動糖份供給;配伍還能夠提高超氧化物歧化酶活力,加快清除自由基,增彊保護組織細胞生物膜作用,延緩疲勞髮生,口服長白山紅景天配伍FDP是安全有效的抗疲勞途徑.
목적：실험연구장백산홍경천배오1,6-이린산과당（FDP）항피노작용,탐토기항피노작용궤제,심조최가배오제량,위연발장백산홍경천배오FDP항피로구복제제제공동물실험의거.방법：시험채용불동제량장백산홍경천화FDP급기배오제량관위소서,통과대력갈유영시간、혈유산함량、간당원함량、SOD활력、유산탈경매활력등적측정,관찰홍경천급기배오FDP항피로효과,병탐토기가능적항피로궤제.결과：장백산홍경천10g/kg、FDP 200mg/kg제량조효과현저.석인분석득출재배오제량하장백산홍경천여FDP존재교호관계,배오제량조강우단제량조,경강우대조조.결론：장백산홍경천여FDP배오가현저증강유산탈경매활력,감소무양운동후유산적퇴적,제고궤체대항피로적능력;현저제고운동후소서간당원수평,증가유양운동당빈공급;배오환능구제고초양화물기화매활력,가쾌청제자유기,증강보호조직세포생물막작용,연완피로발생,구복장백산홍경천배오FDP시안전유효적항피로도경.
Objective：To investigate the anti-fatigue effect of the mixture of R.angusta Nakai and fructose-1,6-diphospphate（FDP） and its mechanism,find out the best dose prescriptions,which provides an experimental basis for further oral use of this mixture in clinical field.Methods：The Experiment group injected different doses of R.angusta Nakai and FDP and different dose prescriptions into mice,through detecting mice exhaustive swimming time,blood lactate,liver glycogen content,SOD activity,lactate dehydrogenase（LDH） activity to observe the anti-fatigue effect of R.angusta Nakai and its compatibility with FDP,and explore the possible anti-fatigue mechanism.Results：The mixture of R.angusta Nakai 10g/kg plus FDP 200mg/kg showed the best effect.Factorial analysis showed that there are mutual effects between R.angusta Nakai and FDP under certain ratio,namely,the mixture group is more effective than either single dose group and is much more effective than control group.Conclusion：The mixture of R.angusta Nakai and FDP can increase activity of LDH and decrease LD accumulation after anaerobic sports to enhance physical anti-fatigue ability.Besides it can improve mice post-exercise hepatic glycogen level to provide more sugar for aerobic athletics.The mixture can also improve SOD activity to remove free radicals scavenging and protect biological membrane of organic cells.Oral take R.angusta Nakai combined with FDP is safe and effective anti-fatigue means.
