中国科学院研究生院学报
中國科學院研究生院學報
중국과학원연구생원학보
JOURNAL OF THE GRADUATE SCHOOL OF THE CHINESE ACADEMY OF SCIENCES
2008年
4期
569-575
,共7页
五味子属%东紫苏%化学成分%抗HIV活性%生源途径
五味子屬%東紫囌%化學成分%抗HIV活性%生源途徑
오미자속%동자소%화학성분%항HIV활성%생원도경
Schisandra species%Elsholtzia bodinieri%chemical constituents%anti-HIV activity%biogenetic origin
对5种五味子属(Schisandra)药用植物(小花五味子Schisandra micrantha,狭叶五味子S. lancifolia,滇翼梗五味子S. henryi var. yunnanensis var. yunnanensis,复瓣黄龙藤S. Plena,华中五味子S. sphenanthera)和唇形科植物东紫苏(Elsholtzia bodinieri)的化学成分进行了研究,从中共分离鉴定了101个化合物,26个为新化合物.首次从3种五味子属植物中发现了3种高度氧化的新奇骨架类型.此外,还发现了18,19-sec-乌索酸型苷和17,20断裂并失去17位侧链的羊毛甾烷型和环阿尔廷型八降三萜等新的骨架类型.对分离得到的部分化合物进行了体外抗HIV-1、急毒、抗炎和抗肿瘤活性实验,发现部分化合物具有抗HIV-1活性.其中化合物SM-10和SM-26具有显著的抑制HIV-1病毒活性,选择指数分别为174.08和25.04,且毒性较小,作为作用于病毒与细胞结合和融合靶点的小分子化合物具有重要的意义.
對5種五味子屬(Schisandra)藥用植物(小花五味子Schisandra micrantha,狹葉五味子S. lancifolia,滇翼梗五味子S. henryi var. yunnanensis var. yunnanensis,複瓣黃龍籐S. Plena,華中五味子S. sphenanthera)和脣形科植物東紫囌(Elsholtzia bodinieri)的化學成分進行瞭研究,從中共分離鑒定瞭101箇化閤物,26箇為新化閤物.首次從3種五味子屬植物中髮現瞭3種高度氧化的新奇骨架類型.此外,還髮現瞭18,19-sec-烏索痠型苷和17,20斷裂併失去17位側鏈的羊毛甾烷型和環阿爾廷型八降三萜等新的骨架類型.對分離得到的部分化閤物進行瞭體外抗HIV-1、急毒、抗炎和抗腫瘤活性實驗,髮現部分化閤物具有抗HIV-1活性.其中化閤物SM-10和SM-26具有顯著的抑製HIV-1病毒活性,選擇指數分彆為174.08和25.04,且毒性較小,作為作用于病毒與細胞結閤和融閤靶點的小分子化閤物具有重要的意義.
대5충오미자속(Schisandra)약용식물(소화오미자Schisandra micrantha,협협오미자S. lancifolia,전익경오미자S. henryi var. yunnanensis var. yunnanensis,복판황룡등S. Plena,화중오미자S. sphenanthera)화진형과식물동자소(Elsholtzia bodinieri)적화학성분진행료연구,종중공분리감정료101개화합물,26개위신화합물.수차종3충오미자속식물중발현료3충고도양화적신기골가류형.차외,환발현료18,19-sec-오색산형감화17,20단렬병실거17위측련적양모치완형화배아이정형팔강삼첩등신적골가류형.대분리득도적부분화합물진행료체외항HIV-1、급독、항염화항종류활성실험,발현부분화합물구유항HIV-1활성.기중화합물SM-10화SM-26구유현저적억제HIV-1병독활성,선택지수분별위174.08화25.04,차독성교소,작위작용우병독여세포결합화융합파점적소분자화합물구유중요적의의.
The chemical constituents and bioactivities of six medicinal plants have been studied. In the study one hundred and one compounds, including twenty-six new compounds were isolated. Among these compounds, sixteen unique highly oxidized nortriterpenoids, belonging to an unprecedented new nortriterpenoid skeleton with a biosynthetically modified eight-membered ring, and unusual nortriterpenoids or bisnortriterpenoid skeletons, have been isolated from three Schisandra species. Interestingly, to date, no naturally occurring triterpenoids have been found to have such a highly modified oxidized norcycloartane skeleton.The bioactivities of compounds isolated from the genus Schisandra have been tested, including anti-HIV-1, anti-inflammatory, and cytotoxities against C8166, MT-4 and K562 cells activities. SM-10 and SM-26 were found to show promising anti-HIV-1 activity and the selectivity index were 174.08 and 25.94, respectively.
