(3aS,6aR)-1,3-二苄基-4-氢-4H-呋喃[3,4-d]咪唑-2,4(1H)-二酮在离子液体中的酶催化水解反应
(3aS,6aR)-1,3-이변기-4-경-4H-부남[3,4-d]미서-2,4(1H)-이동재리자액체중적매최화수해반응
Asymmetric Hydrolysis of (3aS,6aR)-1,3-dibenzyl-tetrahydro-4H-furano[3,4-d]imidazole-2,4(1H)-diketone Catalyzed by Fungal Esterase in Ionic Liquids
  • 万方数据
    合成化学 합성화학
    CHINESE JOURNAL OF SYNTHETIC CHEMISTRY
    2006年 3期 244-248 ,共5页

    刘宝友%杨会龙%许丹倩%徐振元

    류보우%양회룡%허단천%서진원

    离子液体%酶%fusarium sp.%不对称水解%二酮 離子液體%酶%fusarium sp.%不對稱水解%二酮
    리자액체%매%fusarium sp.%불대칭수해%이동
    ionic liquid%esterase%fusarium sp.%asymmetric hydrolysis%diketone
    D,L-(3aS,6aR)-1,3-二苄基-4氢-4H-呋喃[3,4-d]咪唑-2,4(1H)-二酮在BMImBF4离子液体中,于45 ℃酶催化水解反应8 h得D-式异构体,收率45.0%, e. e. 值90.4%.
    D,L-(3aS,6aR)-1,3-이변기-4경-4H-부남[3,4-d]미서-2,4(1H)-이동재BMImBF4리자액체중,우45 ℃매최화수해반응8 h득D-식이구체,수솔45.0%, e. e. 치90.4%.
    A method was developed for direct enantio-selective hydrolysis of D,L-(3aS,6aR)-1,3-dibenzyl-tetrahydro- 4H-furano[3,4-d]imidazole-2,4(1H)-diketone(Ⅰ) to form the corresponding D-(3aS,6aR)-1,3-dibenzyl-tetrahydro-4H-furano[3,4-d]imidazole-2,4(1H)-diketone(Ⅱ) in the presence of a fungal esterase from fusarium sp.. 45.0% yield with 90.4% e. e.was obtained for 8 h at 45 ℃ in an esterase(activity 500 U·g-1)/BMImBF4(1-butyl-3-methylimidazolium tetrafluoroborate) ionic liquids system.
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