Ⅱ型糖尿病肾病和红细胞膜ATP酶活性的关系
Ⅱ형당뇨병신병화홍세포막ATP매활성적관계
Relationship between nephropathy and ATPase activity of erythrocyte membrane in type Ⅱ diabetes
  • 万方数据
    淮海医药 회해의약
    JOURNAL OF HUAIHAI MEDICINE
    2001年 3期 180-181 ,共2页

    汪洪流%黄慧建%李小明%何浩明%田小平

    왕홍류%황혜건%리소명%하호명%전소평

    糖尿病肾病%红细胞膜%Na(+)K(+)转运ATP酶%Ca(2+)Mg(2+)-ATP酶 糖尿病腎病%紅細胞膜%Na(+)K(+)轉運ATP酶%Ca(2+)Mg(2+)-ATP酶
    당뇨병신병%홍세포막%Na(+)K(+)전운ATP매%Ca(2+)Mg(2+)-ATP매
    目的探讨Ⅱ型糖尿病患者红细胞膜Na＋K＋-ATP酶和Ca2＋Mg2＋-ATP酶活性改变参与糖尿病肾病的可能机制。方法按Reinila制膜法测定了25例无糖尿病肾病和57例糖尿病肾病患者红细胞膜Na＋K＋-ATP酶和Ca2＋Mg2＋-ATP酶含量，并与35名正常人作对照。结果糖尿病无肾病组和肾病组红细胞膜Na＋K＋-ATP酶和Ca2＋Mg2＋-ATP酶活性均显著地低于正常人组（P＜0．01），糖尿病肾病组与无肾病组比较差异亦有显著性（P＜0．05）。结论Ⅱ型糖尿病肾病的发生和发展与红细胞膜Na＋K＋-ATP酶和Ca2＋Mg2＋-ATP酶活性有密切的关系。
    목적탐토Ⅱ형당뇨병환자홍세포막Na＋K＋-ATP매화Ca2＋Mg2＋-ATP매활성개변삼여당뇨병신병적가능궤제。방법안Reinila제막법측정료25례무당뇨병신병화57례당뇨병신병환자홍세포막Na＋K＋-ATP매화Ca2＋Mg2＋-ATP매함량，병여35명정상인작대조。결과당뇨병무신병조화신병조홍세포막Na＋K＋-ATP매화Ca2＋Mg2＋-ATP매활성균현저지저우정상인조（P＜0．01），당뇨병신병조여무신병조비교차이역유현저성（P＜0．05）。결론Ⅱ형당뇨병신병적발생화발전여홍세포막Na＋K＋-ATP매화Ca2＋Mg2＋-ATP매활성유밀절적관계。
    Objective To investigate the possible mechanism of nephropathy affected by alteration of activity of Na＋K＋-ATPase and Ca2＋Mg2＋-ATPase of erythrocyte membrane in patients with type Ⅱ diabetes．Methods In 25 diabetic cases without nephropathy and 57 diabetic cases with nephropathy and 35 normal controls，erythrocyte membrance Na＋K＋-ATPase and Ca2＋Mg2＋-ATPase were detected by Reinila method．Results Compared with normal controls，the activity of Na＋K＋-ATPase and Ca2＋Mg2＋-ATPase were decreased significantly in diabetics without and with nephropathy，（P＜0．01），whereas the activity of ATP ase in diabetic nephropathy was lower than those without nephropathy（P＜0．05）．Conclusion The occurrence and development of type Ⅱdiabetic nephropthy is correlated to the decrease of Na＋K＋-ATPase and Ca2＋Mg2＋-ATPase activity of erythrocyte membrane．
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