CAJ | 학술논문

目的：观察醋氨己酸锌(ZAC)治疗消化性溃疡的有效性及安全性。方法：采用随机对照双盲双模拟方法治疗经胃镜检查证实的消化性溃疡135例。ZAC治疗组68例，其中十二指肠溃疡(DU)47例，胃溃疡(GU)21例；应用ZAC 0.3 g,口服，3次/d。西米替丁组67例，其中DU 46例，GU 21例，应用西米替丁0.2 g，口服，3次/d，晚睡前服0.4 g。疗程：DU 4周，GU 6周，结果：溃疡愈合率ZAC组DU为48%，GU为69%；西米替丁组DU为52%，GU为50%，2组比较差异无显著性(P＞0.05)。疼痛症状缓解率ZAC组DU为70%，GU为100%；西米替丁组DU为87%，GU为86%(P＞0.05)；不良反应率ZAC组为16%，西米替丁组为11%(P＞0.05)。结论：ZAC是一种有效的治疗消化性溃疡的药物。
목적：관찰작안기산자(ZAC)치료소화성궤양적유효성급안전성。방법：채용수궤대조쌍맹쌍모의방법치료경위경검사증실적소화성궤양135례。ZAC치료조68례，기중십이지장궤양(DU)47례，위궤양(GU)21례；응용ZAC 0.3 g,구복，3차/d。서미체정조67례，기중DU 46례，GU 21례，응용서미체정0.2 g，구복，3차/d，만수전복0.4 g。료정：DU 4주，GU 6주，결과：궤양유합솔ZAC조DU위48%，GU위69%；서미체정조DU위52%，GU위50%，2조비교차이무현저성(P＞0.05)。동통증상완해솔ZAC조DU위70%，GU위100%；서미체정조DU위87%，GU위86%(P＞0.05)；불량반응솔ZAC조위16%，서미체정조위11%(P＞0.05)。결론：ZAC시일충유효적치료소화성궤양적약물。
Aim: To evaluate the clinical efficacy and safety of zinc acexamate(ZAC) in treating peptic ulcer.Methods:A total of 135 patients with peptic ulcer proven by endoscopy entered arandomized double-blind,double-dummy study.Sixty eight patients received ZAC 0.3 g,3 times per day,including 47 with duodenal ulcer(DU) and 21 with gastric ulcer(GU);67 patients among whom 46 with DU and 21 with GU received cimitidine 0.2 g,3 times per day,and 0.4 g before sleeping in the evening.The course was DU 4 weeks,and GU 6 weeks.Results:There was no difference in DU and GU healing rates of ZAC group and cimitidine group(48% vs 52% and 69% vs 50%,P＞0.05).The pain relief rates of ZAC group and cimitidine group were similar(DU,70% vs 87% and GU,100% vs 86%,P＞0.05).The adverse reaction of ZAC group was 16%,and that of cimitidine group was 11%(P＞0.05).Conclusion:ZAC is an effective drug in the treatment of peptic ulcer.