CAJ | 학술논문

目的研究肺癌患者手术前后血清STNFRI的变化。方法采用ELISA方法测定了80例肺癌患者，14例非肿瘤患者，61例志愿健康成年人。结果肺癌患者中STNFRI的平均水平明显高于健康对照组和非肿瘤组（P＜0.01）。按肿瘤TNM分期，肺癌Ⅲ～Ⅳ期患者远高于Ⅰ～Ⅱ期升高幅度，与疾病分期明显相关，而与病理类型无前(P＜0.01)。结论排除自身免疫疾病和感染，STNFRⅠ的测定对肿瘤的诊断,筛选,预后有辅助意义。也可了解病人的异常免疫状态，为肿瘤患者的免疫治疗提供依据及观察指标。
목적연구폐암환자수술전후혈청STNFRI적변화。방법채용ELISA방법측정료80례폐암환자，14례비종류환자，61례지원건강성년인。결과폐암환자중STNFRI적평균수평명현고우건강대조조화비종류조（P＜0.01）。안종류TNM분기，폐암Ⅲ～Ⅳ기환자원고우Ⅰ～Ⅱ기승고폭도，여질병분기명현상관，이여병리류형무전(P＜0.01)。결론배제자신면역질병화감염，STNFRⅠ적측정대종류적진단,사선,예후유보조의의。야가료해병인적이상면역상태，위종류환자적면역치료제공의거급관찰지표。
Objective To detect the serum levels of STNFR I in lung cancer patients. Methods The serum STNFR I was measured by ELISA. 80 lung cancer patients, 14 non－ tumor patients and 61 healthy volunteers were involved in our study. Results The serum STNFR I in lung cancer patients was higher significantly than healthy control group and non－ tumor group (p＜0.01).The levels of STNFR Ⅰ varied with stages of cancer.but were irrelative with pathology of tumors.The serum levels of STNFR Ⅰ in stage Ⅲ-Ⅳ tumors was higher than that in Ⅰ-Ⅱ tumors(p＜0.01).Conclusion Detection of serum STNFR Ⅰwas of high value in the screening and diagnosis of lung cancer.It also helped to understand the abnormal immune states of patients,and provided a basis for immnotherapy.